Stoltzfus R J, Miller K W, Hakimi M, Rasmussen K M
Division of Nutritional Sciences, Cornell University, Ithaca, NY.
Am J Clin Nutr. 1993 Aug;58(2):167-73. doi: 10.1093/ajcn/58.2.167.
Conjunctival impression cytology (CIC) has been used to assess the vitamin A status of children but not women. We used CIC in a randomized controlled trial of high-dose vitamin A supplementation in Indonesian women. We report its association with biochemical indicators and evaluate its usefulness for several assessment functions, using two definitions for abnormal CIC. Serum retinol concentrations of all women and milk vitamin A concentrations of unsupplemented women decreased with worsening CIC category. CIC indicated risk of low milk vitamin A and low infant serum retinol with low sensitivity and high specificity. CIC did not identify women who benefited from supplementation. The usefulness of CIC to measure response to supplementation was limited by the low prevalence of abnormal status in these women. CIC may be a useful indicator of vitamin A deficiency in women or their breast-fed infants, or to measure response to supplementation, when a more sensitive cutoff point for abnormal status is used.
结膜印迹细胞学检查（CIC）已被用于评估儿童的维生素A状况，但未用于评估女性。我们在一项针对印度尼西亚女性的高剂量维生素A补充剂随机对照试验中使用了CIC。我们报告了其与生化指标的关联，并使用两种异常CIC的定义评估了其在几种评估功能中的效用。所有女性的血清视黄醇浓度以及未补充维生素A的女性的乳汁维生素A浓度均随着CIC类别恶化而降低。CIC显示出低乳汁维生素A和低婴儿血清视黄醇风险，其敏感性低而特异性高。CIC未能识别出从补充剂中获益的女性。这些女性中异常状态的患病率较低，限制了CIC用于衡量补充剂反应的效用。当使用更敏感的异常状态临界值时，CIC可能是女性或其母乳喂养婴儿维生素A缺乏的有用指标，或用于衡量对补充剂的反应。
