原子分辨率下的蛋白质合成：基于核糖体高分辨率结构的翻译机制

Protein synthesis at atomic resolution: mechanistics of translation in the light of highly resolved structures for the ribosome.

作者信息

Wilson Daniel N, Blaha Gregor, Connell Sean R, Ivanov Pavel V, Jenke Holger, Stelzl Ulrich, Teraoka Yoshika, Nierhaus Knud H

机构信息

Max-Planck-Institut für Molekulare Genetik, AG Ribosomen, Ihnestr. 73, Berlin, D-14195 Berlin, Germany.

出版信息

Curr Protein Pept Sci. 2002 Feb;3(1):1-53. doi: 10.2174/1389203023380846.

DOI:10.2174/1389203023380846

PMID:12370010

Abstract

Our understanding of the process of translation has progressed rapidly since the availability of highly resolved structures for the ribosome. A wealth of information has emerged in terms of both RNA and protein structure and the interplay between them. This has prompted us to revisit the astonishing "treasure trove" of functional data regarding the ribosome that has accumulated over the past decades. Here we try a systematic synopsis of these ribosomal functions in light of the cryo-electron microscopic structures (resolution >7 A) and the atomic x-ray structures (>2.4 A) of the ribosome.

摘要

自从核糖体的高分辨率结构可用以来，我们对翻译过程的理解取得了迅速进展。在RNA和蛋白质结构以及它们之间的相互作用方面，已经出现了大量信息。这促使我们重新审视过去几十年积累的关于核糖体的惊人的功能数据“宝库”。在这里，我们根据核糖体的冷冻电子显微镜结构（分辨率>7 Å）和原子X射线结构（>2.4 Å），尝试对这些核糖体功能进行系统概述。