核糖体结构与翻译机制。
Ribosome structure and the mechanism of translation.
作者信息
Ramakrishnan V
机构信息
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom.
出版信息
Cell. 2002 Feb 22;108(4):557-72. doi: 10.1016/s0092-8674(02)00619-0.
Abstract
The publication of crystal structures of the 50S and 30S ribosomal subunits and the intact 70S ribosome is revolutionizing our understanding of protein synthesis. This review is an attempt to correlate the structures with biochemical and genetic data to identify the gaps and limits in our current knowledge of the mechanisms involved in translation.
摘要
50S和30S核糖体亚基以及完整的70S核糖体晶体结构的发表，正在彻底改变我们对蛋白质合成的理解。这篇综述试图将这些结构与生化和遗传数据相关联，以找出我们目前对翻译机制认识中的差距和局限。
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