Chen Wenchieh, Hsieh Fu-Sen
Department of Dermatology, College of Medicine, National Cheng Kung University, 138 Sheng-Li Road, 704 Tainan, Taiwan.
Eur J Dermatol. 2002 Sep-Oct;12(5):488-90.
The non-steroidal anti-inflammatory drugs, especially various pyrazole or pyrazolon derivatives, were one of the classes of drugs commonly implicated in erythema multiforme or Stevens-Johnson syndrome/toxic epidermal necrolysis. Reticular exanthem was a rare morphological pattern of maculopapular drug eruptions. Here we report a case of dimorphic exanthema presenting with partly reticular maculopapular exanthema and erythema multiforme-like lesions, associated with pyrazolon derivatives. Patch testing showed negative reaction to the suspected drugs. The possible mechanism underlying the association of dimorphic exanthema with NSAIDs is discussed.
非甾体抗炎药，尤其是各种吡唑或吡唑啉酮衍生物，是常与多形红斑或史蒂文斯-约翰逊综合征/中毒性表皮坏死松解症相关的一类药物。网状疹是斑丘疹性药疹的一种罕见形态学表现。本文报告1例双形疹病例，其表现为部分网状斑丘疹及多形红斑样损害，与吡唑啉酮衍生物有关。斑贴试验对可疑药物呈阴性反应。本文讨论了双形疹与非甾体抗炎药相关的可能机制。
