[慢性吸入二氧化硫对小鼠骨髓细胞诱导产生微核]

[Micronuclei induced by chronic inhalation of SO2 in mouse bone marrow cells].

作者信息

Meng Ziqiang, Ruan Aidong, Sang Nan, Zhang Bo, Zhang Jianbiao

机构信息

Institute of Environmental and Toxicology, Department of Life Sciences, Shanxi University, Taiyuan 030006.

出版信息

Huan Jing Ke Xue. 2002 Jul;23(4):123-5.

PMID:12371093

Abstract

In the chronic inhalation experiment of sulfur dioxide(SO2), micronuclei(MN) frequencies in the polychromatophilic erythroblasts(PCE) of mouse bone marrow and the frequencies of cells with MN were significantly increased in dose-dependent manner. There was a significant difference between the male and the female animals. The results also showed that SO2 inhibited urethone-induced MN formation. These results furtherly confirm that SO2 inhalation was a clastogenic and genotoxic agent to mammalian cells, and the combined effects of SO2 and other mutagens are complex.

摘要

在二氧化硫（SO₂）的慢性吸入实验中，小鼠骨髓嗜多染红细胞（PCE）中的微核（MN）频率以及含微核细胞的频率呈剂量依赖性显著增加。雄性和雌性动物之间存在显著差异。结果还表明，SO₂抑制了乌拉坦诱导的微核形成。这些结果进一步证实，吸入SO₂对哺乳动物细胞具有致断裂和遗传毒性作用，并且SO₂与其他诱变剂的联合作用是复杂的。