Meng Ziqiang, Ruan Aidong, Sang Nan, Zhang Bo, Zhang Jianbiao
Institute of Environmental and Toxicology, Department of Life Sciences, Shanxi University, Taiyuan 030006.
Huan Jing Ke Xue. 2002 Jul;23(4):123-5.
In the chronic inhalation experiment of sulfur dioxide(SO2), micronuclei(MN) frequencies in the polychromatophilic erythroblasts(PCE) of mouse bone marrow and the frequencies of cells with MN were significantly increased in dose-dependent manner. There was a significant difference between the male and the female animals. The results also showed that SO2 inhibited urethone-induced MN formation. These results furtherly confirm that SO2 inhalation was a clastogenic and genotoxic agent to mammalian cells, and the combined effects of SO2 and other mutagens are complex.
在二氧化硫（SO₂）的慢性吸入实验中，小鼠骨髓嗜多染红细胞（PCE）中的微核（MN）频率以及含微核细胞的频率呈剂量依赖性显著增加。雄性和雌性动物之间存在显著差异。结果还表明，SO₂抑制了乌拉坦诱导的微核形成。这些结果进一步证实，吸入SO₂对哺乳动物细胞具有致断裂和遗传毒性作用，并且SO₂与其他诱变剂的联合作用是复杂的。
