Li Guangke, Sang Nan, Zhao Youcai
College of Environment and Resource, Shanxi University, Taiyuan, Shanxi 030006, People's Republic of China.
Environ Res. 2004 May;95(1):77-81. doi: 10.1016/j.envres.2003.10.007.
The induction of micronuclei (MN) in polychromatic erythrocytes (PCE) of mouse bone marrow by municipal landfill leachate was studied in vivo. Results showed that mouse exposure via drinking water containing various concentrations of leachate caused a significant increase of MN frequencies in a concentration (Chemical oxygen demand measured with potassium dichromate oxidation, COD(Cr))-dependent manner. MN induction in female and male mice was different at higher concentrations. This implies that leachate is a genotoxic agent in mammalian cells and that exposure to leachate in an aquatic environment may pose a potential genotoxic risk to human beings.
对城市垃圾填埋场渗滤液在小鼠骨髓多染红细胞（PCE）中诱导微核（MN）的情况进行了体内研究。结果表明，小鼠通过饮用含有不同浓度渗滤液的水，微核频率呈浓度（以重铬酸钾氧化法测定的化学需氧量，COD（Cr））依赖性显著增加。在较高浓度下，雌性和雄性小鼠的微核诱导情况有所不同。这意味着渗滤液是哺乳动物细胞中的一种遗传毒性剂，在水生环境中接触渗滤液可能对人类构成潜在的遗传毒性风险。
