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大鼠肾脏髓袢短支中的葡萄糖转运。通过转运常数对其进行表征。

Glucose transport in the short loop of Henle of the rat kidney. Its characterisation by transport constants.

作者信息

Von Baeyer H

出版信息

Pflugers Arch. 1975 Sep 29;359(4):317-23. doi: 10.1007/BF00581442.

Abstract

Short loops of Henle in rat kidneys were perfused with proximal tubular equilibrium solutions containing radioactive D-glucose. The transport rates follow 2-parameter kinetics: Km = 5.7 mmol/I. Vmax - 145 X 10(-12) MOL/MIN-1; Phlorrhizin inhibits transport almost completely, indicating little passive diffusion of D-glucose. The glucose transport capacity in the short loops of Henle, presumably in the pars rects, is much smaller than that in superficial segments.

摘要

用含有放射性D-葡萄糖的近端小管平衡溶液灌注大鼠肾脏的短袢髓袢。转运速率符合双参数动力学:Km = 5.7 mmol/L,Vmax = 145×10⁻¹² mol/min⁻¹;根皮苷几乎完全抑制转运,表明D-葡萄糖的被动扩散很少。髓袢短袢(可能是直部)中的葡萄糖转运能力远小于浅表节段中的转运能力。

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