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[基因:生命与疾病的推动者]

[Genes: movers of life and disease].

作者信息

Burny A, Demonté D, Van Lint C

出版信息

Bull Mem Acad R Med Belg. 2001;156(10-12):533-44.

Abstract

Genes are elements of the genetic material (deoxyribonucleic acid, dna). They code for a protein product. The human genome contains 35,000 genes. Half of our genetic information is inherited from our father, the other half from our mother. Mitrochondria and their DNA are entirely of maternal origin, which allowed Bryan Sykes to establish that modern human subjects can be classified into seven different lineages. The seven daughters of Eve, Bryan Sykes, 2001). Some genes code for structural proteins, some others code for regulatory ones. The efficient control of the cell cycle is carried out by numerous "normal" proteins. Some proteins, mutated on "abnormally" regulated are inducers of diseases, such as cancers or degenerative diseases.

摘要

基因是遗传物质(脱氧核糖核酸,DNA)的组成部分。它们编码一种蛋白质产物。人类基因组包含35000个基因。我们一半的遗传信息来自父亲,另一半来自母亲。线粒体及其DNA完全来自母系,这使得布莱恩·赛克斯能够确定现代人类个体可被分为七个不同的谱系。夏娃的七个女儿(布莱恩·赛克斯,2001年)。一些基因编码结构蛋白,另一些编码调节蛋白。细胞周期的有效控制由众多“正常”蛋白质执行。一些发生突变或“异常”调节的蛋白质是疾病的诱导因素,如癌症或退行性疾病。

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