Reynolds John N J, Wickens Jeffery R
The Neuroscience Research Centre, University of Otago, Dunedin, New Zealand.
Neural Netw. 2002 Jun-Jul;15(4-6):507-21. doi: 10.1016/s0893-6080(02)00045-x.
Knowledge of the effect of dopamine on corticostriatal synaptic plasticity has advanced rapidly over the last 5 years. We consider this new knowledge in relation to three factors proposed earlier to describe the rules for synaptic plasticity in the corticostriatal pathway. These factors are a phasic increase in dopamine release, presynaptic activity and postsynaptic depolarisation. A function is proposed which relates the amount of dopamine release in the striatum to the modulation of corticostriatal synaptic efficacy. It is argued that this function, and the experimental data from which it arises, are compatible with existing models which associate the reward-related firing of dopamine neurons with changes in corticostriatal synaptic efficacy.
在过去5年里，关于多巴胺对皮质纹状体突触可塑性影响的知识有了迅速进展。我们结合之前提出的三个因素来考量这一新知识，这三个因素用于描述皮质纹状体通路中突触可塑性的规则。这些因素是多巴胺释放的阶段性增加、突触前活动和突触后去极化。本文提出了一个函数，该函数将纹状体中多巴胺的释放量与皮质纹状体突触效能的调节联系起来。有人认为，这个函数及其所依据的实验数据与现有的模型相符，这些模型将多巴胺神经元与奖励相关的放电与皮质纹状体突触效能的变化联系起来。
