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钙依赖性磷酸二酯酶 1 调节纹状体棘突投射神经元谷氨酸能突触的可塑性。

Ca-dependent phosphodiesterase 1 regulates the plasticity of striatal spiny projection neuron glutamatergic synapses.

机构信息

Department of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA.

出版信息

Cell Rep. 2024 Aug 27;43(8):114540. doi: 10.1016/j.celrep.2024.114540. Epub 2024 Jul 25.

DOI:10.1016/j.celrep.2024.114540
PMID:39058595
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11426333/
Abstract

Long-term synaptic plasticity at glutamatergic synapses on striatal spiny projection neurons (SPNs) is central to learning goal-directed behaviors and habits. Our studies reveal that SPNs manifest a heterosynaptic, nitric oxide (NO)-dependent form of long-term postsynaptic depression of glutamatergic SPN synapses (NO-LTD) that is preferentially engaged at quiescent synapses. Plasticity is gated by Ca entry through Ca1.3 Ca channels and phosphodiesterase 1 (PDE1) activation, which blunts intracellular cyclic guanosine monophosphate (cGMP) and NO signaling. Both experimental and simulation studies suggest that this Ca-dependent regulation of PDE1 activity allows for local regulation of dendritic cGMP signaling. In a mouse model of Parkinson disease (PD), NO-LTD is absent because of impaired interneuronal NO release; re-balancing intrastriatal neuromodulatory signaling restores NO release and NO-LTD. Taken together, these studies provide important insights into the mechanisms governing NO-LTD in SPNs and its role in psychomotor disorders such as PD.

摘要

谷氨酸能突触在纹状体棘突投射神经元（SPN）上的长期突触可塑性是学习目标导向行为和习惯的核心。我们的研究表明，SPN 表现出一种异突触、一氧化氮（NO）依赖性的谷氨酸能 SPN 突触的长时程突触后抑制形式（NO-LTD），这种形式优先在静止突触中被激活。可塑性由通过 Ca1.3 钙通道和磷酸二酯酶 1（PDE1）激活的 Ca 内流门控，这会削弱细胞内环鸟苷酸单磷酸（cGMP）和 NO 信号。实验和模拟研究都表明，这种 Ca 依赖性的 PDE1 活性调节允许局部调节树突 cGMP 信号。在帕金森病（PD）的小鼠模型中，由于中间神经元 NO 释放受损，NO-LTD 缺失；重新平衡纹状体中的神经调质信号会恢复 NO 释放和 NO-LTD。总之，这些研究为 SPN 中 NO-LTD 的调控机制及其在帕金森病等精神运动障碍中的作用提供了重要的见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/147e/11426333/c9a202ca8582/nihms-2019518-f0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/147e/11426333/d45226983677/nihms-2019518-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/147e/11426333/2c7eb4ad94d5/nihms-2019518-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/147e/11426333/aadcd630e84d/nihms-2019518-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/147e/11426333/f218768e8129/nihms-2019518-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/147e/11426333/166a776165af/nihms-2019518-f0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/147e/11426333/1bee5276d4c1/nihms-2019518-f0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/147e/11426333/c9a202ca8582/nihms-2019518-f0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/147e/11426333/d45226983677/nihms-2019518-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/147e/11426333/2c7eb4ad94d5/nihms-2019518-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/147e/11426333/aadcd630e84d/nihms-2019518-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/147e/11426333/f218768e8129/nihms-2019518-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/147e/11426333/166a776165af/nihms-2019518-f0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/147e/11426333/1bee5276d4c1/nihms-2019518-f0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/147e/11426333/c9a202ca8582/nihms-2019518-f0008.jpg

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4
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