Di Lorenzo Gabriele, Vitale Francesco, Pacor Maria Luisa, Pellitteri Maria Esposito, Drago Agata, Cucchiara Rosaria, Seroni Gianpiero, Intonazzo Vincenza, Romano Nino, Caruso Calogero
Dipartimento di Medicina Clinica e delle Patologie Emergenti, Universita' di Palermo, Italy.
J Investig Allergol Clin Immunol. 2002;12(2):114-9.
To assess the prevalence of latex sensitization in a group of hospital employees in a general hospital.
Cross-sectional study on hypersensitivity to latex gloves among health-care workers.
A general hospital in Palermo, Sicily.
196 health-care workers answered a questionnaire about their case history of allergic diseases (i. e., rhinitis and/or asthma) and about symptoms after wearing latex gloves. All subjects were tested by skin prick test (SPT) with commercial latex extract and aeroallergens and had blood draw for total serum IgE and latex-specific IgE testing and glove-use test.
42% of the subjects who answered the questionnaire reported at least one symptom after wearing latex gloves. All symptoms were local, and none of the subjects reported systemic reactions. The most common symptom was itching, but none of subjects with only itching presented a positive SPT or specific serum IgE to latex. The SPT to latex was positive in 19 of 196 subjects (9.7%). Specific IgE to latex were found in 15/196 subjects (7.6%). Glove-use test was positive in 14/196 (7.1%).
The overall prevalence of latex sensitivity in health-care workers in our epidemiological setting is 7.1%. An accurate diagnosis must take in account the integration of in vivo and in vitro tests with previous history of allergic disease.
评估一家综合医院的一组医院员工中乳胶致敏的患病率。
针对医护人员对乳胶手套过敏的横断面研究。
西西里岛巴勒莫的一家综合医院。
196名医护人员回答了一份关于他们过敏性疾病病史（即鼻炎和/或哮喘）以及佩戴乳胶手套后症状的问卷。所有受试者均接受了商用乳胶提取物和气源性变应原的皮肤点刺试验（SPT），并进行了静脉采血以检测血清总IgE和乳胶特异性IgE，以及手套使用试验。
回答问卷的受试者中有42%报告在佩戴乳胶手套后至少出现一种症状。所有症状均为局部症状，没有受试者报告有全身反应。最常见的症状是瘙痒，但仅有瘙痒症状的受试者中没有一人对乳胶的皮肤点刺试验或特异性血清IgE呈阳性。196名受试者中有19人（9.7%）对乳胶的皮肤点刺试验呈阳性。196名受试者中有15人（7.6%）检测到乳胶特异性IgE。手套使用试验中14/196呈阳性（7.1%）。
在我们的流行病学研究中，医护人员乳胶敏感性的总体患病率为7.1%。准确的诊断必须考虑体内和体外试验与既往过敏性疾病史的综合情况。
