Spencer Pamela J, Crissman James W, Stott William T, Corley Richard A, Cieszlak Frank S, Schumann Alan M, Hardisty Jerry F
Toxicology and Environmental Research and Consulting, The Dow Chemical Company, Midland, Michigan 48674, USA.
Toxicol Pathol. 2002 Sep-Oct;30(5):570-9. doi: 10.1080/01926230290105848.
A series of inhalation studies with propylene glycol monomethyl ether (PGME) vapor were undertaken to characterize its subchronic toxicity in mice and chronic toxicity/oncogenicity in rats and mice. Groups of male and female Fischer 344 rats and B6C3F1 mice were exposed to 0, 300, 1,000, or 3,000 ppm vapor from 1 week to 2 years. Primary treatment-related effects included: initial sedation of animals exposed to 3,000 ppm and its subsequent resolution correlating with induction of hepatic mixed function oxidase activity and S-phase DNA synthesis; elevated mortality in high-exposure male rats and mice (chronic study); elevated deposition of alpha2u-globulin (alpha2U-G) and associated nephropathy and S-phase DNA synthesis in male rat kidneys; accelerated atrophy of the adrenal gland X-zone in female mice (subchronic study only); and increased occurrence and/or severity of eosinophilic foci of altered hepatocytes in male rats. No toxicologically relevant statistically significant increases in neoplasia occurred in either species. A numerical increase in the incidence of kidney adenomas occurred in intermediate-exposure male rats; however, the association with alpha2U-G nephropathy, a male rat specific effect, indicated a lack of relevance for human risk assessment.
开展了一系列关于丙二醇单甲醚（PGME）蒸气的吸入研究，以表征其对小鼠的亚慢性毒性以及对大鼠和小鼠的慢性毒性/致癌性。将雄性和雌性Fischer 344大鼠及B6C3F1小鼠分组，使其在1周龄至2岁期间暴露于浓度为0、300、1000或3000 ppm的PGME蒸气中。与处理相关的主要影响包括：暴露于3000 ppm的动物最初出现镇静作用，随后该作用消失，这与肝脏混合功能氧化酶活性的诱导及S期DNA合成有关；高暴露组的雄性大鼠和小鼠死亡率升高（慢性研究）；雄性大鼠肾脏中α2u球蛋白（α2U-G）沉积增加、相关肾病及S期DNA合成增加；雌性小鼠肾上腺X区加速萎缩（仅亚慢性研究）；雄性大鼠中肝细胞嗜酸性病灶的发生率和/或严重程度增加。两种动物在肿瘤形成方面均未出现与毒理学相关的统计学显著增加。中等暴露组的雄性大鼠肾腺瘤发生率出现数字上的增加；然而，鉴于其与α2U-G肾病（一种雄性大鼠特有的效应）相关，表明其对人类风险评估缺乏相关性。
