• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

严重酒精擦手剂摄入过量导致昏迷,甲型 H1N1 流感大流行后需注意。

Severe alcohol hand rub overdose inducing coma, watch after H1N1 pandemic.

机构信息

Service de Réanimation, Centre Hospitalier de Versailles, 177 Rue de Versailles, 78157 Le Chesnay, France.

出版信息

Neurocrit Care. 2010 Jun;12(3):400-2. doi: 10.1007/s12028-009-9319-4.

DOI:10.1007/s12028-009-9319-4
PMID:20052624
Abstract

BACKGROUND

Alcoholic hand rubs (AHRs) have been proven effective in preventing nosocomial infections, and healthcare authorities include AHRs use among quality-of-care criteria. Since the onset of the influenza A (H1N1) pandemic, AHRs have gained considerable popularity among the general public.

METHODS

We report a case of intentional AHRs self-poisoning inducing rapid coma with hyperlactatemia, and a full recovery. The relevant literature was reviewed. To our knowledge, this is the third reported case of intentional AHRs poisoning. 3 patients presented with a picture of acute alcohol intoxication, of variable severity depending on the amount ingested and speed of ingestion.

RESULTS

The blood alcohol level was 414 mg/dl and tests for other drugs were performed 30 min after admission. The blood lactate level increased briefly to 4.8 mmol/l, without renal or hepatic function disturbances. She regained consciousness after 6 h then achieved a full recovery allowing extubation and readmission to the psychiatric ward after 24 h. She reported gulping down the entire contents of the Aniosgel bottle.

CONCLUSION

Whereas overdrinking in social settings (wine and liquor) leads to a gradual increase in blood alcohol levels, AHRs poisoning is usually characterized by a sudden massive alcohol load. The unusual nature of the alcohol source may lead to diagnostic wanderings. AHRs are currently available in bottles that facilitate the ingestion of large amounts. Unit-dose packaging or dispensing might decrease the risk of AHRs poisoning.

摘要

背景

酒精擦手液(AHRs)已被证明能有效预防医院感染,医疗保健当局将其使用纳入了护理质量标准。自甲型 H1N1 流感大流行以来,AHRs 在公众中变得非常流行。

方法

我们报告了一例故意使用 AHRs 自我中毒导致快速昏迷和高乳酸血症,并完全康复的病例。回顾了相关文献。据我们所知,这是第三例故意 AHRs 中毒报告。3 名患者表现为急性酒精中毒的症状,严重程度取决于摄入的量和速度。

结果

血液酒精水平为 414mg/dl,入院 30 分钟后进行了其他药物检测。血乳酸水平短暂升高至 4.8mmol/L,无肾功能或肝功能障碍。她在 6 小时后恢复了意识,24 小时后拔管并重新入住精神病病房后完全康复。她报告说吞下了整瓶 Aniosgel。

结论

虽然在社交场合(葡萄酒和白酒)过度饮酒会导致血液酒精水平逐渐升高,但 AHRs 中毒通常表现为突然大量摄入酒精。酒精来源的不寻常性质可能导致诊断上的困惑。AHRs 目前有便于大量摄入的瓶装。单位剂量包装或配药可能会降低 AHRs 中毒的风险。

相似文献

1
Severe alcohol hand rub overdose inducing coma, watch after H1N1 pandemic.严重酒精擦手剂摄入过量导致昏迷,甲型 H1N1 流感大流行后需注意。
Neurocrit Care. 2010 Jun;12(3):400-2. doi: 10.1007/s12028-009-9319-4.
2
Alcohol hand rubs: hygiene and hazard.酒精擦手液:卫生与危害
BMJ. 2007 Dec 1;335(7630):1154-5. doi: 10.1136/bmj.39274.583472.AE.
3
Efficacy of soap and water and alcohol-based hand-rub preparations against live H1N1 influenza virus on the hands of human volunteers.肥皂水洗手法和酒精类擦手剂对人类志愿者手上活H1N1流感病毒的效果。
Clin Infect Dis. 2009 Feb 1;48(3):285-91. doi: 10.1086/595845.
4
[Carbamazepine poisoning: protracted course with development of intestinal atony and hepatic toxicity].[卡马西平中毒:病程迁延,出现肠道无力和肝毒性]
Wien Klin Wochenschr. 1994;106(1):27-9.
5
Pandemic (H1N1) 2009 influenza in hospitalized children in Manitoba: nosocomial transmission and lessons learned from the first wave.曼尼托巴省住院儿童中的大流行性(H1N1)2009 流感:医院内传播以及第一波疫情中吸取的教训。
Infect Control Hosp Epidemiol. 2011 May;32(5):435-43. doi: 10.1086/659401.
6
Altered mental status due to pruno intoxication.因饮用自酿酒中毒导致的精神状态改变。
J Emerg Med. 2014 Jun;46(6):767-8. doi: 10.1016/j.jemermed.2013.11.125. Epub 2014 Mar 27.
7
[Clinical aspects of acute intoxication with ethanol].[乙醇急性中毒的临床方面]
Przegl Lek. 2004;61(4):314-6.
8
The 2009 H1N1 influenza A pandemic and hand hygiene practices in a hospital in the South of Brazil.2009年甲型H1N1流感大流行与巴西南部一家医院的手部卫生习惯
Infect Control Hosp Epidemiol. 2010 Dec;31(12):1313-5. doi: 10.1086/657582.
9
Severe Acute Valproic Acid Intoxication Successfully Treated with Liver Support Therapy.肝支持疗法成功治疗严重急性丙戊酸中毒
Basic Clin Pharmacol Toxicol. 2017 Oct;121(4):368-370. doi: 10.1111/bcpt.12807. Epub 2017 Jun 27.
10
Novel (pandemic) influenza A H1N1 in healthcare facilities: implications for prevention and control.医疗机构中的新型(大流行)甲型H1N1流感:对预防和控制的影响
Scand J Infect Dis. 2010 Jul;42(6-7):412-20. doi: 10.3109/00365541003699649.

引用本文的文献

1
S2k-Guideline hand antisepsis and hand hygiene.S2k指南:手部消毒与手部卫生
GMS Hyg Infect Control. 2024 Sep 6;19:Doc42. doi: 10.3205/dgkh000497. eCollection 2024.
2
A retrospective review of calls to the Poisons Information Helpline of the Western Cape during the first 6 months of the COVID-19 pandemic in South Africa.对南非新冠疫情头6个月期间拨打西开普省中毒信息热线的情况进行的回顾性研究。
S Afr J Infect Dis. 2022 Mar 30;37(1):391. doi: 10.4102/sajid.v37i1.391. eCollection 2022.
3
Putatively lethal ingestion of isopropyl alcohol-related case: interpretation of post mortem isopropyl alcohol and acetone concentrations remains challenging.

本文引用的文献

1
Novel H1N1 influenza and respiratory protection for health care workers.新型甲型H1N1流感与医护人员的呼吸防护
N Engl J Med. 2009 Nov 5;361(19):1823-5. doi: 10.1056/NEJMp0908437. Epub 2009 Sep 30.
2
A surprising side effect of hand antisepsis.手部消毒的一个惊人副作用。
Intensive Care Med. 2005 Nov;31(11):1600. doi: 10.1007/s00134-005-2814-y. Epub 2005 Sep 27.
3
An unusual complication of hand hygiene.手部卫生的一种罕见并发症。
疑似致命性摄入异丙醇相关案例:死后异丙醇和丙酮浓度的解读仍然具有挑战性。
Int J Legal Med. 2021 Jan;135(1):175-182. doi: 10.1007/s00414-020-02444-4. Epub 2020 Oct 22.
4
The rising incidence of intentional ingestion of ethanol-containing hand sanitizers.有意摄入含乙醇的手部消毒剂导致发病率上升。
Crit Care Med. 2012 Jan;40(1):290-4. doi: 10.1097/CCM.0b013e31822f09c0.
Anaesthesia. 2005 Jan;60(1):100-1. doi: 10.1111/j.1365-2044.2004.04055.x.
4
Propylene glycol monomethyl ether (PGME): inhalation toxicity and carcinogenicity in Fischer 344 rats and B6C3F1 mice.丙二醇单甲醚(PGME):对Fischer 344大鼠和B6C3F1小鼠的吸入毒性和致癌性
Toxicol Pathol. 2002 Sep-Oct;30(5):570-9. doi: 10.1080/01926230290105848.