转录激活：揭示TFIID的本质特性
Transcription activation: unveiling the essential nature of TFIID.
作者信息
Chen Bo-Shiun, Hampsey Michael
机构信息
Department of Biochemistry, Division of Nucleic Acids Enzymology, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA.
出版信息
Curr Biol. 2002 Sep 17;12(18):R620-2. doi: 10.1016/s0960-9822(02)01134-x.
Abstract
The TAF subunits of TFIID mediate activation of subsets of the eukaryotic genome. Recent results demonstrate that TFIID is recruited to promoters in an activator-specific manner involving functional interaction between upstream regulatory elements and the core promoter, thereby coordinating the expression of distinct sets of genes.
摘要
TFIID的TAF亚基介导真核生物基因组子集的激活。最近的研究结果表明，TFIID以一种激活因子特异性的方式被招募到启动子上，这种方式涉及上游调控元件与核心启动子之间的功能相互作用，从而协调不同基因集的表达。
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