Dobbins Ian G, Foley Heather, Schacter Daniel L, Wagner Anthony D
Martinos Center for Biomedical Imaging, MGH/MIT/HMS, Charlestown, MA 02129, USA.
Neuron. 2002 Aug 29;35(5):989-96. doi: 10.1016/s0896-6273(02)00858-9.
During recognition, one may sense items as familiar (item memory) and additionally recollect specific contextual details of the earlier encounters (source memory). Cognitive theory suggests that, unlike item memory, source memory requires controlled cue specification and monitoring processes. Functional imaging suggests that such processes may depend on left prefrontal cortex (PFC). However, the nature and possible anatomical segregation of these processes remains unknown. Using functional magnetic resonance imaging, we isolated distinct response patterns in left PFC during source memory consistent with semantic analysis/cue specification (anterior ventrolateral), recollective monitoring (posterior dorsolateral and frontopolar), and phonological maintenance/rehearsal (posterior ventrolateral). Importantly, cue specification and recollective monitoring responses were not seen during item memory and were unaffected by retrieval success, demonstrating that the mere attempt to recollect episodic detail engages multiple control processes with different left PFC substrates.
在识别过程中，人们可能会感觉某些物品很熟悉（项目记忆），并额外回忆起早期接触时的特定背景细节（来源记忆）。认知理论表明，与项目记忆不同，来源记忆需要受控的线索指定和监控过程。功能成像表明，这些过程可能依赖于左前额叶皮质（PFC）。然而，这些过程的性质和可能的解剖学分离仍然未知。我们使用功能磁共振成像，在来源记忆期间在左PFC中分离出与语义分析/线索指定（前腹外侧）、回忆监控（后背外侧和额极）以及语音维持/复述（后腹外侧）一致的不同反应模式。重要的是，在项目记忆期间未观察到线索指定和回忆监控反应，并且这些反应不受检索成功的影响，这表明仅仅尝试回忆情景细节就会涉及多个具有不同左PFC底物的控制过程。
