CA19-9与CA125在子宫内膜异位症诊断中的效用比较。
Usefulness of CA19-9 versus CA125 for the diagnosis of endometriosis.
作者信息
Harada Tatsuya, Kubota Toshiro, Aso Takeshi
机构信息
Department of Comprehensive Reproductive Medicine, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan.
出版信息
Fertil Steril. 2002 Oct;78(4):733-9. doi: 10.1016/s0015-0282(02)03328-9.
OBJECTIVE
To investigate the clinical value of the serum CA19-9 level in comparison with the serum CA125 level for diagnosing and determining the severity of endometriosis.
DESIGN
Retrospective study.
SETTING
Department of Comprehensive Reproductive Medicine in a university hospital.
PATIENT(S): One hundred one women with endometriosis and 22 without endometriosis participated in this study.
INTERVENTION(S): Blood samples were collected before the operation (laparoscopy, oophrectomy, cystectomy, and/or hysterectomy), and tissue samples of ovarian chocolate cysts were collected during the operation.
MAIN OUTCOME MEASURE(S): The serum CA19-9 and CA125 levels and the localization of these antigens in ovarian chocolate cysts.
RESULT(S): The mean serum CA19-9 levels in patients at all stages of endometriosis were significantly higher than those in patients without endometriosis, and serum CA19-9 levels significantly correlated with the Revised American Fertility Society classification scores. Intense staining of CA19-9 was observed in 15 of the 20 samples of ovarian chocolate cysts.
CONCLUSION(S): CA19-9 is a useful marker for determining the severity of endometriosis.
目的
比较血清CA19-9水平与血清CA125水平在诊断和确定子宫内膜异位症严重程度方面的临床价值。
设计
回顾性研究。
地点
某大学医院综合生殖医学科。
患者
101例子宫内膜异位症患者和22例非子宫内膜异位症患者参与本研究。
干预措施
术前（腹腔镜检查、卵巢切除术、囊肿切除术和/或子宫切除术）采集血样，术中采集卵巢巧克力囊肿组织样本。
主要观察指标
血清CA19-9和CA125水平以及这些抗原在卵巢巧克力囊肿中的定位。
结果
子宫内膜异位症各阶段患者的血清CA19-9平均水平显著高于非子宫内膜异位症患者，且血清CA19-9水平与美国生殖医学学会修订分类评分显著相关。在20个卵巢巧克力囊肿样本中的15个中观察到CA19-9的强染色。
结论
CA19-9是确定子宫内膜异位症严重程度的有用标志物。
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