Harada Tatsuya, Kubota Toshiro, Aso Takeshi
Department of Comprehensive Reproductive Medicine, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan.
Fertil Steril. 2002 Oct;78(4):733-9. doi: 10.1016/s0015-0282(02)03328-9.
To investigate the clinical value of the serum CA19-9 level in comparison with the serum CA125 level for diagnosing and determining the severity of endometriosis.
Retrospective study.
Department of Comprehensive Reproductive Medicine in a university hospital.
PATIENT(S): One hundred one women with endometriosis and 22 without endometriosis participated in this study.
INTERVENTION(S): Blood samples were collected before the operation (laparoscopy, oophrectomy, cystectomy, and/or hysterectomy), and tissue samples of ovarian chocolate cysts were collected during the operation.
MAIN OUTCOME MEASURE(S): The serum CA19-9 and CA125 levels and the localization of these antigens in ovarian chocolate cysts.
RESULT(S): The mean serum CA19-9 levels in patients at all stages of endometriosis were significantly higher than those in patients without endometriosis, and serum CA19-9 levels significantly correlated with the Revised American Fertility Society classification scores. Intense staining of CA19-9 was observed in 15 of the 20 samples of ovarian chocolate cysts.
CONCLUSION(S): CA19-9 is a useful marker for determining the severity of endometriosis.
比较血清CA19-9水平与血清CA125水平在诊断和确定子宫内膜异位症严重程度方面的临床价值。
回顾性研究。
某大学医院综合生殖医学科。
101例子宫内膜异位症患者和22例非子宫内膜异位症患者参与本研究。
术前（腹腔镜检查、卵巢切除术、囊肿切除术和/或子宫切除术）采集血样，术中采集卵巢巧克力囊肿组织样本。
血清CA19-9和CA125水平以及这些抗原在卵巢巧克力囊肿中的定位。
子宫内膜异位症各阶段患者的血清CA19-9平均水平显著高于非子宫内膜异位症患者，且血清CA19-9水平与美国生殖医学学会修订分类评分显著相关。在20个卵巢巧克力囊肿样本中的15个中观察到CA19-9的强染色。
CA19-9是确定子宫内膜异位症严重程度的有用标志物。
