Talukdar Souvanik, Singh Santosh K, Mishra Manoj K, Singh Rajesh
Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, GA 30310, USA.
Cancer Biology Research and Training, Department of Biological Sciences, Alabama State University, Montgomery, AL 36104, USA.
Nanomaterials (Basel). 2024 Jun 5;14(11):976. doi: 10.3390/nano14110976.
Endometriosis, an incurable gynecological disease that causes abnormal growth of uterine-like tissue outside the uterine cavity, leads to pelvic pain and infertility in millions of individuals. Endometriosis can be treated with medicine and surgery, but recurrence and comorbidities impair quality of life. In recent years, nanoparticle (NP)-based therapy has drawn global attention, notably in medicine. Studies have shown that NPs could revolutionize conventional therapeutics and imaging. Researchers aim to enhance the prognosis of endometriosis patients with less invasive and more effective NP-based treatments. This study evaluates this potential paradigm shift in endometriosis management, exploring NP-based systems for improved treatments and diagnostics. Insights into nanotechnology applications, including gene therapy, photothermal therapy, immunotherapy, and magnetic hyperthermia, offering a theoretical reference for the clinical use of nanotechnology in endometriosis treatment, are discussed in this review.
子宫内膜异位症是一种无法治愈的妇科疾病，它会导致子宫腔外出现类似子宫组织的异常生长，致使数百万患者遭受盆腔疼痛和不孕之苦。子宫内膜异位症可以通过药物和手术进行治疗，但复发和合并症会损害生活质量。近年来，基于纳米颗粒（NP）的疗法引起了全球关注，尤其是在医学领域。研究表明，纳米颗粒可以彻底改变传统治疗方法和成像技术。研究人员旨在通过侵入性更小、更有效的基于纳米颗粒的治疗方法来改善子宫内膜异位症患者的预后。本研究评估了子宫内膜异位症管理中这一潜在的范式转变，探索基于纳米颗粒的系统以实现更好的治疗和诊断。本综述讨论了对纳米技术应用的见解，包括基因治疗、光热治疗、免疫治疗和磁热疗，为纳米技术在子宫内膜异位症治疗中的临床应用提供理论参考。
