短小酰胺，一种从海洋海绵小地海绵中提取的新型螺环倍半萜，它在海胆胚胎发育过程中抑制细胞命运特化。
Exiguamide, a new spirocyclic sesquiterpene from the marine sponge Geodia exigua that inhibits cell fate specification during sea urchin embryogenesis.
作者信息
Uy Mylene M, Ohta Shinji, Yanai Mihoko, Ohta Emi, Hirata Toshifumi, Ikegami Susumu
机构信息
Department of Mathematical and Life Sciences, Graduate School of Science, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima 739-8526, Japan.
出版信息
Bioorg Med Chem Lett. 2002 Nov 4;12(21):3037-9. doi: 10.1016/s0960-894x(02)00662-5.
Abstract
A new nitrogen-containing bicyclic spirosesquiterpene designated exiguamide which inhibited cell fate specification during sea urchin embryogenesis has been isolated from the marine sponge Geodia exigua. Its structure was determined by interpretation of spectral data and X-ray crystallographic analysis.
摘要
从海洋海绵微小地穴海绵（Geodia exigua）中分离出一种新的含氮双环螺倍半萜，命名为微小酰胺（exiguamide），它在海胆胚胎发育过程中抑制细胞命运特化。通过光谱数据解析和X射线晶体学分析确定了其结构。
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