Bowden Bruce F, McCool Brian J, Willis Richard H
Department of Chemistry, School of Pharmacy and Molecular Sciences, James Cook University, Townsville, Qld 4811, Australia.
J Org Chem. 2004 Nov 12;69(23):7791-3. doi: 10.1021/jo0498819.
An investigation of a new species of sponge from the genus Suberea collected at Lihou Reef in the Coral Sea afforded lihouidine, an unprecedented cytotoxic spiro nonacyclic polyaromatic alkaloid. The structure of the alkaloid, which was racemic, was determined by a combination of 1D and 2D NMR techniques and single-crystal X-ray structural analysis.
对在珊瑚海利厚礁采集的一种来自Suberea属的新海绵物种进行的研究得到了利厚定，一种前所未有的具有细胞毒性的螺环九环多芳族生物碱。该生物碱为外消旋体，其结构通过一维和二维核磁共振技术以及单晶X射线结构分析确定。
