肌苷单磷酸脱氢酶抑制剂中心二酰胺部分的环状取代物研究。
A survey of cyclic replacements for the central diamide moiety of inhibitors of inosine monophosphate dehydrogenase.
作者信息
Dhar T G Murali, Liu Chunjian, Pitts William J, Guo Junquing, Watterson Scott H, Gu Henry, Fleener Catherine A, Rouleau Katherine, Sherbina N Z, Barrish Joel C, Hollenbaugh Diane, Iwanowicz Edwin J
机构信息
Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543-4000, USA.
出版信息
Bioorg Med Chem Lett. 2002 Nov 4;12(21):3125-8. doi: 10.1016/s0960-894x(02)00641-8.
A series of heterocyclic replacements for the central diamide moiety of 1, a potent small molecule inhibitor of inosine monophosphate dehydrogenase (IMPDH) were explored The synthesis and the structure-activity relationships (SARs), derived from in vitro studies, for these new series of inhibitors is given.
探索了一系列用于1（一种有效的肌苷单磷酸脱氢酶（IMPDH）小分子抑制剂）中心二酰胺部分的杂环取代物。给出了这些新系列抑制剂的合成以及源自体外研究的构效关系（SARs）。
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