新型基于二酰胺的肌苷-5'-单磷酸脱氢酶抑制剂。
Novel diamide-based inhibitors of IMPDH.
作者信息
Gu Henry H, Iwanowicz Edwin J, Guo Junqing, Watterson Scott H, Shen Zhongqi, Pitts William J, Dhar T G Murali, Fleener Catherine A, Rouleau Katherine, Sherbina N Z, Witmer Mark, Tredup Jeffrey, Hollenbaugh Diane
机构信息
Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543-4000, USA.
出版信息
Bioorg Med Chem Lett. 2002 May 6;12(9):1323-6. doi: 10.1016/s0960-894x(02)00132-4.
Abstract
A series of novel amide-based small molecule inhibitors of inosine monophosphate dehydrogenase is described. The synthesis and the structure-activity relationships (SARs) derived from in vitro studies are presented.
摘要
描述了一系列新型的基于酰胺的肌苷单磷酸脱氢酶小分子抑制剂。介绍了体外研究得出的合成方法及构效关系（SAR）。
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