Klimek Violetta, Schenck Jane E, Han Hui, Stockmeier Craig A, Ordway Gregory A
Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson 39216, USA.
Biol Psychiatry. 2002 Oct 1;52(7):740-8. doi: 10.1016/s0006-3223(02)01383-5.
A deficiency of mesolimbic dopamine (DA) is a leading candidate for the etiology of certain symptoms of depression (e.g., anhedonia and loss of motivation). Here we show amounts of dopaminergic proteins in the amygdala, a key brain structure involved in the integration of emotions and stress, in subjects with major depression and in psychiatrically normal control subjects.
The specific binding of [(125)I]RTI 55 to the DA transporter, [(3)H]SCH 23390 to the D1 receptor and [(125)I]epidepride to D2/D3 receptors were measured in the right amygdaloid complex in postmortem brains from 11 subjects with major depression and 11 matched control subjects.
The binding of [(125)I]RTI 55 to DA transporter was significantly lower in the basal and central amygdaloid nuclei, whereas the binding of [(125)I]epidepride to D2/D3 receptors was significantly higher in the basal, central, and lateral amygdaloid nuclei in major depression compared with control subjects. No difference in the binding of [(3)H]SCH 23390 to D1 receptors was observed.
Given that DA depletion in rats can induce a reduction in the DA transporter and an upregulation of D2/D3 receptors, our data are consistent with the hypothesis that major depression is associated with a deficiency of mesolimbic DA.
中脑边缘多巴胺（DA）缺乏是某些抑郁症状（如快感缺失和动机丧失）病因的主要候选因素。在此，我们展示了重度抑郁症患者和精神正常对照者杏仁核（参与情绪和压力整合的关键脑结构）中多巴胺能蛋白的含量。
在11名重度抑郁症患者和11名匹配对照者的死后大脑右杏仁复合体中，测量了[(125)I]RTI 55与DA转运体、[(3)H]SCH 23390与D1受体以及[(125)I]表哌啶与D2/D3受体的特异性结合。
与对照者相比，重度抑郁症患者基底杏仁核和中央杏仁核中[(125)I]RTI 55与DA转运体的结合显著降低，而基底杏仁核、中央杏仁核和外侧杏仁核中[(125)I]表哌啶与D2/D3受体的结合显著升高。未观察到[(3)H]SCH 23390与D1受体结合的差异。
鉴于大鼠体内DA耗竭可导致DA转运体减少和D2/D3受体上调，我们的数据与重度抑郁症与中脑边缘DA缺乏相关的假设一致。
