Kallmes David F, Fujiwara Naomi H
Department of Radiology, University of Virginia Health Services, Charlottesville, VA, USA.
AJNR Am J Neuroradiol. 2002 Oct;23(9):1580-8.
This study introduces a new, hybrid embolic device that in addition to offering all the important attributes of existing detachable platinum coils also shows an enhanced ability to fill aneurysm cavities. The device consists of a carrier platinum coil coupled to an expandable hydrogel material, which undergoes a ninefold increase in volume when placed into a physiological environment. Distinct from previous devices aimed at speeding the organization of thrombus, the new device has been designed to entirely fill the aneurysm cavity, with complete or near-complete exclusion of thrombus. Unlike thrombus, the hydrogel material is stable and unaffected by natural thrombolytic processes and thus may diminish observed rates of aneurysm recanalization. We report the angiographic and histologic findings of the new, hybrid device used to treat experimental aneurysms in rabbits.
本研究介绍了一种新型的混合栓塞装置，该装置除具备现有可脱卸铂线圈的所有重要特性外，还显示出更强的填充动脉瘤腔的能力。该装置由一个与可膨胀水凝胶材料相连的载体铂线圈组成，当置于生理环境中时，水凝胶材料的体积会增大九倍。与以往旨在加速血栓形成的装置不同，新装置的设计目的是完全填充动脉瘤腔，使血栓完全或几乎完全被排除。与血栓不同，水凝胶材料稳定，不受自然溶栓过程的影响，因此可能会降低观察到的动脉瘤再通率。我们报告了用于治疗兔实验性动脉瘤的新型混合装置的血管造影和组织学结果。
