Heimbach D, Jacobs D, Winter P, Hesse A
Department of Urology, Rheinische Friedrich-Wilhelms-Universität, Bonn, Germany.
J Endourol. 1997 Feb;11(1):63-6. doi: 10.1089/end.1997.11.63.
In studying the dissolution of stones in vitro, the advantage of artificial stones in comparison to natural stones is that one can get substance-specific standardized and reproducible results. Our investigations were performed with artificial stones composed of natural material (calcium apatite). These stones were of spherical form and consisted of layers built up around a core. They were comparable to natural stones in their physical properties. Litholysis was performed in a special apparatus with continuous exposure to Suby G solution under standard conditions. Natural stones of the same chemical composition served as a reference. Statistical measurements were performed. By hardening of the artificial stones, it was possible to reach a dissolution comparable to natural stones composed of calcium apatite depending on the Suby G concentration (artificial 2.5 resp. 4.75 mg/h; natural 2.18 resp. 4.2 mg/h). For the first time, an artificial stone model has been created with reproducible behaviour in response to chemolitholysis and with properties of dissolution comparable to those of natural stones of identical chemical composition.
在体外研究结石溶解时，人造结石相较于天然结石的优势在于，人们能够获得物质特异性的标准化且可重复的结果。我们的研究使用的是由天然材料（钙磷灰石）制成的人造结石。这些结石呈球形，由围绕核心形成的多层结构组成。它们在物理性质上与天然结石相当。溶石过程在一种特殊装置中进行，在标准条件下持续暴露于苏比G溶液。具有相同化学成分的天然结石用作对照。进行了统计测量。通过硬化人造结石，根据苏比G浓度，有可能达到与由钙磷灰石构成的天然结石相当的溶解程度（人造结石分别为2.5和4.75毫克/小时；天然结石分别为2.18和4.2毫克/小时）。首次创建了一种人造结石模型。该模型在化学溶石方面具有可重复的行为，并且其溶解特性与具有相同化学成分的天然结石相当。
