Sierig Gabriele, Labitzke Birgit, Diez Ulrike, Kiess Wieland, Borte Michael
Children's Hospital, University of Leipzig, Germany.
Biol Neonate. 2002;82(3):159-65. doi: 10.1159/000063614.
Infections are a significant cause of morbidity and mortality among low birth weight (LBW) infants.
(1) to investigate whether serum antibody concentrations in 62 LBW infants (1,500-2,500 g) were normalized by 1 year of life, and (2) to determine the clinical relevance of humoral immaturity in these children during the 1st year compared to 20 appropriate-for-gestational-age (AGA) term infants. At 1 year of life, immunoglobulin serum concentrations in LBW infants were comparable to those of the control group. The incidence of respiratory tract infections during the 1st year of life was not significantly different between LBW and AGA term infants. Interestingly, we demonstrated that LBW infants with a higher frequency of reported febrile upper respiratory tract infections had more elevated serum total IgG, IgG(1), IgG(3), total IgA, and IgA(1) concentrations. Thus, infants with a birth weight of 1,500-2,500 g do not appear to have an increased risk of respiratory tract infections compared to AGA term children during the 1st year of life. Furthermore, our data suggest that especially febrile infections induce higher serum immunoglobulin concentrations in LBW infants.
感染是低出生体重（LBW）婴儿发病和死亡的重要原因。
（1）调查62名低出生体重婴儿（1500 - 2500克）的血清抗体浓度在1岁时是否恢复正常，以及（2）确定与20名适于胎龄（AGA）足月儿相比，这些儿童在出生后第1年体液免疫不成熟的临床相关性。在1岁时，低出生体重婴儿的免疫球蛋白血清浓度与对照组相当。低出生体重婴儿和适于胎龄足月儿在出生后第1年呼吸道感染的发生率没有显著差异。有趣的是，我们发现报告的发热性上呼吸道感染频率较高的低出生体重婴儿血清总IgG、IgG(1)、IgG(3)、总IgA和IgA(1)浓度升高更明显。因此，出生体重为1500 - 2500克的婴儿在出生后第1年与适于胎龄足月儿相比，呼吸道感染风险似乎并未增加。此外，我们的数据表明，尤其是发热性感染会导致低出生体重婴儿血清免疫球蛋白浓度升高。
