早产儿免疫球蛋白谱及淋巴细胞亚群。
Immunoglobulin Profile and Lymphocyte Subsets in Preterm Neonates.
机构信息
Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh.
Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh. Correspondence to: Prof Kanya Mukhopadhyay, Division of Neonatology, Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh 160 012.
出版信息
Indian Pediatr. 2022 Mar 15;59(3):214-217. doi: 10.1007/s13312-022-2470-0. Epub 2022 Jan 5.
OBJECTIVE
We documented the immunological profile of neonates and mothers, and lymphocyte subsets at birth.
METHODS
Consecutively born preterm neonates (26 to 31 weeks gestation) at our level III neonatal unit, fulfilling the inclusion criteria were enrolled. Immunoglobulin levels were assessed in maternal blood and in cord blood along with T cell subsets.
RESULTS
A total of 115 neonates were enrolled. The mean cord levels for IgG, IgM and IgA, respectively were 5.34, 0.10 and 0.04 g/L and of B, T, NK and NK-T cells were 14%, 71%, 10% and 1%, respectively of total lymphocyte population. Cord IgG and IgA levels showed a significantly rising trend with increasing gestation (P=0.005 and 0.02, respectively) but not IgM and T cell subsets. Maternal immunoglobulins were similar in all gestations.
CONCLUSION
The cord IgG and IgA increased with increasing gestation but not IgM in neonates.
目的
我们记录了新生儿和母亲的免疫学特征，以及出生时的淋巴细胞亚群。
方法
在我们的三级新生儿病房中，连续出生的早产儿（26 至 31 周妊娠）符合纳入标准，即被纳入研究。在母血和脐血中评估免疫球蛋白水平以及 T 细胞亚群。
结果
共纳入 115 例新生儿。脐带血中 IgG、IgM 和 IgA 的平均水平分别为 5.34、0.10 和 0.04 g/L，B、T、NK 和 NK-T 细胞分别占总淋巴细胞群的 14%、71%、10%和 1%。脐带血 IgG 和 IgA 水平随胎龄增加呈显著上升趋势（分别为 P=0.005 和 0.02，但 IgM 和 T 细胞亚群无此变化）。所有胎龄的产妇免疫球蛋白相似。
结论
新生儿脐带血 IgG 和 IgA 随胎龄增加而增加，但 IgM 无此变化。
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