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经耳电刺激对大鼠吗啡戒断综合征的影响:耳针疗法的实验范式

Modification of morphine-withdrawal syndrome in rats following transauricular electrostimulation: an experimental paradigm for auricular electroacupuncture.

作者信息

Ng L K, Douthitt T C, Thoa N B, Albert C A

出版信息

Biol Psychiatry. 1975 Oct;10(5):575-80.

PMID:1237325
Abstract

The experimental paradigm reported here provides a useful animal model with which to further study the effects of regional electrostimulation and its possible relationship with electrical acupuncture. What similarities there may be between electrical acupuncture and the technique of regional electrocerebral stimulation used for production of electrosleep and electronarcosis in animals and man (Wageneder et al., 1966) remain to be elucidated. Further research studies, both clinical and basic, are clearly needed to answer some of the questions relating to the safety, efficacy, and possible mechanisms by which a technique such as electrical acupuncture may exert its effects.

摘要

本文报道的实验范式提供了一个有用的动物模型,可用于进一步研究局部电刺激的效果及其与电针可能的关系。电针与用于在动物和人类中产生电睡眠和电麻醉的局部脑电刺激技术(Wageneder等人,1966年)之间可能存在的相似之处仍有待阐明。显然需要进一步开展临床和基础研究,以回答一些与电针等技术的安全性、有效性及其可能发挥作用的机制相关的问题。

相似文献

1
Modification of morphine-withdrawal syndrome in rats following transauricular electrostimulation: an experimental paradigm for auricular electroacupuncture.经耳电刺激对大鼠吗啡戒断综合征的影响:耳针疗法的实验范式
Biol Psychiatry. 1975 Oct;10(5):575-80.
2
Experimental "auricular electroacupuncture" in morphine-dependent rats: behavioral and biochemical observations.吗啡依赖大鼠的实验性“耳针疗法”:行为学和生物化学观察
Am J Chin Med (Gard City N Y). 1975 Oct;3(4):335-41. doi: 10.1142/s0192415x75000402.
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Auricular acupuncture in animals: effects of opiate withdrawal and involvement of endorphins.动物耳针疗法:阿片类药物戒断的影响及内啡肽的作用
J Altern Complement Med. 1996 Spring;2(1):61-3; discussion 73-5. doi: 10.1089/acm.1996.2.61.
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[Drug dependence in the animal model. Therapy of the drug withdrawal syndrome using ear electroacupuncture].[动物模型中的药物依赖。采用耳部电针疗法治疗药物戒断综合征]
MMW Munch Med Wochenschr. 1976 Sep 10;118(37):1157-8.
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Electroacupuncture attenuates morphine withdrawal signs and c-Fos expression in the central nucleus of the amygdala in freely moving rats.电针可减轻自由活动大鼠杏仁核中央核中的吗啡戒断症状及c-Fos表达。
Brain Res. 2005 May 24;1044(2):155-63. doi: 10.1016/j.brainres.2005.02.075. Epub 2005 Apr 15.
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[Problems in quantification of provoked morphine withdrawal in rats].[大鼠诱发吗啡戒断反应的量化问题]
Arzneimittelforschung. 1974 Jul;24(7):1012-4.
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Effect of electro-acupuncture on behavioral responses and plasma levels of ACTH and TSH in naloxone-induced morphine withdrawal in rats.电针对纳洛酮诱发的大鼠吗啡戒断反应及血浆促肾上腺皮质激素和促甲状腺激素水平的影响。
Am J Chin Med. 1980 Spring-Summer;8(1-2):167-9. doi: 10.1142/s0192415x80000128.
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The influence of electro-acupuncture on naloxone-induced morphine withdrawal. II. Elevation of immunoassayable beta-endorphin activity in the brain but not the blood.电针对纳洛酮诱发的吗啡戒断反应的影响。II. 脑内而非血液中可免疫测定的β-内啡肽活性升高。
Am J Chin Med. 1979 Autumn;7(3):237-40. doi: 10.1142/s0192415x79000192.
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Trans-cranial electrical stimulation attenuates abrupt morphine withdrawal in rats assayed by remote computerized quantification of multiple motor behavior indices.经颅电刺激可减轻大鼠因远程计算机量化多种运动行为指标所检测到的突然吗啡戒断反应。
Eur J Pharmacol. 1990 Jan 10;175(2):187-95. doi: 10.1016/0014-2999(90)90229-y.
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[Comparison of the development of morphine dependence and morphine tolerance in rats].[大鼠吗啡依赖性与吗啡耐受性发展的比较]
Arzneimittelforschung. 1974 Jul;24(7):1014-5.

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Exp Anim. 2018 Jul 30;67(3):383-392. doi: 10.1538/expanim.18-0014. Epub 2018 Apr 20.
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The History, Mechanism, and Clinical Application of Auricular Therapy in Traditional Chinese Medicine.中医耳穴疗法的历史、机制及临床应用
Evid Based Complement Alternat Med. 2015;2015:495684. doi: 10.1155/2015/495684. Epub 2015 Dec 28.
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Acupuncture and related interventions for smoking cessation.
针灸及相关戒烟干预措施
Cochrane Database Syst Rev. 2014 Jan 23;2014(1):CD000009. doi: 10.1002/14651858.CD000009.pub4.
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Recent advances in the understanding of acupuncture.针刺疗法认识的最新进展。
Yale J Biol Med. 1978 Jan-Feb;51(1):55-65.