Dougherty P M, Dong W Q, Faillace L A, Dafny N
Department of Neurobiology and Anatomy, University of Texas Health Science Center, Houston 77225.
Eur J Pharmacol. 1990 Jan 10;175(2):187-95. doi: 10.1016/0014-2999(90)90229-y.
The goal of the present study was to assess the effects of trans-cranial electrical stimulation on the behavioral signs of the abrupt withdrawal syndrome of rats. However, this goal also necessitated the introduction of an experimental model measuring animal behavior for prolonged periods of time using a computerized animal activity monitoring system to quantify spontaneous motor activities associated with abstinence behavior. Comparable withdrawal severity was obtained by both the activity monitoring system and investigator observation of motor signs of abstinence behavior. Moreover, using this system we demonstrate a time-dependent effect of electrical stimulation in reducing the severity of various indices of motor hyperactivity associated with abrupt morphine withdrawal in rats.
本研究的目的是评估经颅电刺激对大鼠突然戒断综合征行为体征的影响。然而，这一目标还需要引入一种实验模型，该模型使用计算机化动物活动监测系统长时间测量动物行为，以量化与戒断行为相关的自发运动活动。活动监测系统和研究人员对戒断行为运动体征的观察都获得了相当的戒断严重程度。此外，使用该系统，我们证明了电刺激在降低大鼠突然吗啡戒断相关的各种运动亢进指标严重程度方面具有时间依赖性效应。
