Nagao Y, Tomonari R, Kage M, Komai K, Tsubone K, Kamura T, Sata M
Research Center for Innovative Cancer Therapy, Kurume University School of Medicine, Kurume, Fukuoka, Japan.
Int J Mol Med. 2002 Nov;10(5):569-73.
Lichen planus (LP), common mucocutaneous disorder, involves not only oral mucosa and skin but genitalia membrane. LP is frequently seen in patients with HCV infection. This study evaluated patients with HCV-associated oral lichen planus (OLP) for vulvar and vaginal LP involvement, and the possible intraspousal transmission of HCV. We examined a total of 24 female Japanese patients with OLP for genitalia LP: 14 OLP-HCV positive and 10 OLP-HCV negative. All subjects were evaluated for genital LP by a gynecologist. All 24 subjects and 10 of the husbands were tested for anti-HCV and serum HCV RNA. Vulvar LP was observed in 10 (41.7%) of 24 patients with OLP. Vulvar LP in 14 (OLP-HCV positive) and 10 patients (OLP-HCV negative) were observed in 42.9 and 40%, respectively. There were no significant differences (age, sites of OLP, blood transfusion, HCV infection, and degree of liver diseases) between the vulvar LP and non-vulvar LP patients. Two spouses of 10 married couples were shown to be infected with HCV. In one couple with HCV infection, the wife and husband had also erosive OLP, the wife had erosive vulvar LP. In conclusion, the majority of OLP patients suffered from genitalia LP in Japan. Clinicians should follow the OLP patients with sufficient attention to the presence of extraoral manifestations. These data may suggest the occurrence of intraspousal transmission of HCV through erosive vulvar LP.
扁平苔藓（LP）是一种常见的黏膜皮肤疾病，不仅累及口腔黏膜和皮肤，还可累及生殖器黏膜。LP在丙型肝炎病毒（HCV）感染患者中较为常见。本研究评估了HCV相关口腔扁平苔藓（OLP）患者外阴和阴道LP的累及情况以及HCV可能的配偶间传播。我们共检查了24例日本女性OLP患者的生殖器LP情况：14例OLP-HCV阳性，10例OLP-HCV阴性。所有受试者均由妇科医生评估生殖器LP情况。对所有24例受试者及其10名丈夫进行了抗-HCV和血清HCV RNA检测。24例OLP患者中有10例（41.7%）观察到外阴LP。14例（OLP-HCV阳性）和10例（OLP-HCV阴性）患者中观察到外阴LP的比例分别为42.9%和40%。外阴LP患者与非外阴LP患者之间在年龄、OLP部位、输血史、HCV感染情况及肝病程度方面无显著差异。10对已婚夫妇中有2对配偶被证实感染HCV。在一对均感染HCV的夫妇中，妻子和丈夫均患有糜烂性OLP，妻子还患有糜烂性外阴LP。总之，在日本，大多数OLP患者患有生殖器LP。临床医生应对OLP患者给予充分关注，留意有无口外表现。这些数据可能提示HCV可通过糜烂性外阴LP在配偶间传播。
