Lin Liang-Ho, Lu Shin-Yu, Lu Sheng-Nan
Department of Dentistry, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010 Mar;109(3):408-14. doi: 10.1016/j.tripleo.2009.10.005. Epub 2010 Jan 22.
A possible association between oral lichen planus (OLP) and hepatitis C virus (HCV) infection has been documented in certain populations such as Japan and Southern Europe; however, the issue remains controversial. The aim of this study was to investigate the prevalence of HCV antibodies among patients with OLP in Southern Taiwan, and to assess the possible association between OLP and HCV infection. All patients enrolled in the study sought care at a hospital dental clinic. Serum samples of 104 patients with OLP and 100 controls with healthy oral mucosa, whose age and gender were matched, were respectively screened for anti-HCV antibodies by the microparticle enzyme immunoassay (AxSYM HCV version 3.0). The prevalence of HCV infection was 22.1% in the study group (23 of 104 OLP patients) and 2% in the control group (2 of 100 control subjects) respectively (P < .001). Eleven of 23 HCV-infected OLP patients (47.8%) were unaware of their HCV infection status in the study. A positive association between OLP and HCV in Southern Taiwan exists, suggesting that routine HCV infection testing of patients with OLP in Southern Taiwan should be considered.
在日本和南欧等特定人群中，已证实口腔扁平苔藓（OLP）与丙型肝炎病毒（HCV）感染之间可能存在关联；然而，这一问题仍存在争议。本研究的目的是调查台湾南部OLP患者中HCV抗体的流行情况，并评估OLP与HCV感染之间可能存在的关联。所有纳入本研究的患者均在一家医院牙科诊所就诊。采用微粒酶免疫分析法（AxSYM HCV 3.0版）分别对104例OLP患者和100例口腔黏膜健康的对照者（年龄和性别相匹配）的血清样本进行抗HCV抗体筛查。研究组中HCV感染率为22.1%（104例OLP患者中有23例），对照组为2%（100例对照者中有2例）（P < 0.001）。在本研究中，23例HCV感染的OLP患者中有11例（47.8%）不知道自己的HCV感染状况。台湾南部的OLP与HCV之间存在正相关，这表明应考虑对台湾南部的OLP患者进行常规HCV感染检测。
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