皮质酮对大鼠肛门尾骨肌胆碱酯酶活性的降低作用。
Reduction in the cholinesterase activity of the rat anococcygeus muscle produced by corticosterone.
作者信息
Gibson A, Pollock D
出版信息
Br J Pharmacol. 1975 Sep;55(1):69-72. doi: 10.1111/j.1476-5381.1975.tb07612.x.
1 Administration of corticosterone caused a 47% reduction in the cholinesterase (ChE) activity of homogenates of the rat anococcygeus muscle. 2 ChE activity was also reduced by morphine withdrawal and this effect was abolished by the corticosteroid synthesis inhibitor, metyrapone. 3 A single dose of reserpine reduced ChE activity in normal but not in adrenalectomized rats. 4 ChE activity was increased by adrenalectomy or by metyrapone treatment. 5 The mechanism of the corticosteroid-induced reduction in ChE activity is discussed. 6 The reduction in ChE activity produced by corticosterone, morphine withdrawal, or a single dose of reserpine might explain the leftward shift of the dose-% response curve to acetylcholine produced by these procedures in the isolated anococcygeus muscle of the rat.
给予皮质酮可使大鼠肛门尾骨肌匀浆的胆碱酯酶（ChE）活性降低47%。
吗啡戒断也会降低ChE活性，而皮质类固醇合成抑制剂美替拉酮可消除这种作用。
单剂量利血平可降低正常大鼠而非肾上腺切除大鼠的ChE活性。
肾上腺切除术或美替拉酮治疗可增加ChE活性。
讨论了皮质类固醇诱导ChE活性降低的机制。
皮质酮、吗啡戒断或单剂量利血平引起的ChE活性降低，可能解释了这些操作在大鼠离体肛门尾骨肌中使乙酰胆碱剂量-反应曲线向左移位的原因。
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