钠离子可能参与大鼠肛门尾骨肌中皮质酮诱导的高收缩性。
The possible involvement of Na+ ions in corticosterone-induced hypercontractility in the rat anococcygeus muscle.
作者信息
Gibson A, Pollock D
出版信息
Br J Pharmacol. 1976 Aug;57(4):559-63. doi: 10.1111/j.1476-5381.1976.tb10385.x.
The possibility that corticosterone-induced hypercontractility in the rat anococcygeus muscle might be due to an intramuscular redistribution of Na+ was investigated. 2 The contractility of the isolated muscle to noradrenaline (NA) was directly dependent on the Na+ concentration of the Krebs solution. 3 There was a linear relationship between the maximum contractile response of the muscle to NA and the Na+ concentration of the Krebs solution. 4 Muscle contractility was also increased by the presence of ouabain (10(-4)M) in the bathing medium. 5 Muscles from rats treated with corticosterone exhibited increases in both total and ouabain-sensitive ATPase activity. 6 The relationship between corticosterone, Na+ distribution, and muscle contractility is discussed.
研究了皮质酮诱导大鼠肛门尾骨肌高收缩性可能是由于肌肉内Na⁺重新分布的可能性。2 离体肌肉对去甲肾上腺素（NA）的收缩性直接取决于Krebs溶液中的Na⁺浓度。3 肌肉对NA的最大收缩反应与Krebs溶液中的Na⁺浓度之间存在线性关系。4 浴液中存在哇巴因（10⁻⁴M）也会增加肌肉收缩性。5 用皮质酮处理的大鼠的肌肉，其总ATP酶活性和对哇巴因敏感的ATP酶活性均增加。6 讨论了皮质酮、Na⁺分布和肌肉收缩性之间的关系。
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