Kostrzewa R M, Kostrzewa J P, Brus R
Department of Pharmacology, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, USA.
Amino Acids. 2002;23(1-3):57-63. doi: 10.1007/s00726-001-0110-x.
Despite its being the most efficacious drug for symptom reversal in Parkinson's disease (PD), there is concern that chronic levodopa (L-DOPA) treatment may be detrimental. In this paper we review the potential for L-DOPA to 1). autoxidize from a catechol to a quinone, and 2). generate other reactive oxygen species (ROS). Overt toxicity and neuroprotective effects of L-DOPA, both in vivo and in vitro, are described in the context of whether L-DOPA may accelerate or delay progression of human Parkinson's disease.
尽管左旋多巴是治疗帕金森病（PD）症状逆转最有效的药物，但人们担心长期使用左旋多巴治疗可能有害。在本文中，我们综述了左旋多巴可能：1）从儿茶酚自氧化为醌，以及2）产生其他活性氧（ROS）的可能性。在左旋多巴是否会加速或延缓人类帕金森病进展的背景下，描述了其在体内和体外的明显毒性及神经保护作用。
