Shoham S, Youdim M B H
Research Department, Herzog Hospital, Jerusalem.
J Neural Transm (Vienna). 2002 Oct;109(10):1241-56. doi: 10.1007/s00702-002-0710-y.
Iron deficiency (ID), the most prevalent nutritional disorder in the world, impairs cognition in early development. The involvement of hippocampus in cognition has prompted investigation into distribution of the iron storage protein ferritin (FER) in rat hippocampus. (a) In normal rats, FER positive cells appeared first in lateral CA3 and hilus of dentate gyrus and then spread over the entire mossy fiber (MF) system. No such spread was observed in CA1 field. (b) Nutritional iron deficiency retarded development of FER in the MF system. No change in FER was observed in CA1 field. (c) Zinc distribution can be altered by iron deficiency. Thus, the effect of zinc added to iron supplementation was tested in iron-deficient rats. Significant FER recovery was observed only in hippocampal MF of rats receiving both zinc and iron. It is apparent that for accelerating recovery of hippocampal function in iron deficiency, both zinc and iron are required.
缺铁（ID）是世界上最普遍的营养失调症，会损害早期发育中的认知能力。海马体参与认知过程，这促使人们对大鼠海马体中铁储存蛋白铁蛋白（FER）的分布进行研究。（a）在正常大鼠中，FER阳性细胞首先出现在齿状回的外侧CA3和海马门，然后扩散到整个苔藓纤维（MF）系统。在CA1区域未观察到这种扩散。（b）营养性缺铁会延缓MF系统中FER的发育。在CA1区域未观察到FER的变化。（c）缺铁会改变锌的分布。因此，在缺铁大鼠中测试了补充铁时添加锌的效果。仅在同时接受锌和铁的大鼠的海马MF中观察到显著的FER恢复。显然，为了加速缺铁时海马功能的恢复，锌和铁都是必需的。
