Muslimatun S, Schmidt M K, West C E, Schultink W, Gross R, Hautvast J G A J
SEAMEO TROPMED Regional Center for Community Nutrition, Jakarta, Indonesia.
Eur J Clin Nutr. 2002 Oct;56(10):947-51. doi: 10.1038/sj.ejcn.1601439.
To investigate the determinants of neonatal weight and length.
From 16-20 week of pregnancy, 366 mothers of the neonates had participated in the community-based study to investigate the effect of weekly supplementation during pregnancy with iron and vitamin A on infant growth. Women from five villages were allocated randomly to receive two tablets each containing 60 mg iron as ferrous sulphate and 250 micro g folic acid (n=121) or two tablets each containing 2400 RE vitamin A in addition to the same amount of ferrous sulphate and folic acid (n=122). A third ('daily') group (n=123) participating in the national iron supplementation programme was recruited from four neighbouring villages.
Neonatal weight and length did not differ between the two weekly groups and between the weekly iron group and the 'daily' group. Iron and vitamin A status during pregnancy did not influence neonatal weight and length significantly. Boys were 100 g heavier and 0.53 cm longer than girls (P<0.05). First born neonates were lighter (P<0.01) and tended to be shorter (P=0.070) than neonates of higher birth order. Maternal age and education as well as other socioeconomic determinants were not associated with neonatal weight and length. Neonatal weight was 32% explained by gestational age, maternal weight, postnatal measurement, gender and parity, while neonatal length was 28% explained by gestational age, maternal weight, postnatal measurement, gender and maternal height.
Gestational age, maternal weight at second trimester and infant gender were the main predictors of neonatal weight and length.
The study was supported by The Netherlands Organization for Scientific Research-Netherlands Foundation for the Advancement of Tropical Research (NWO-WOTRO; WV 93-280) and Neys-van Hoogstraten Foundation (IN 114), The Netherlands, and German Agency for Technical Cooperation (GTZ)/South East Asian Ministers of Education Organization (SEAMEO), Indonesia.
研究新生儿体重和身长的决定因素。
从妊娠16至20周起,366名新生儿的母亲参与了一项基于社区的研究,以调查孕期每周补充铁和维生素A对婴儿生长的影响。来自五个村庄的妇女被随机分配,分别接受两片各含60毫克硫酸亚铁铁和250微克叶酸的片剂(n = 121),或除相同量的硫酸亚铁和叶酸外,再加两片各含2400视黄醇当量维生素A的片剂(n = 122)。第三个(“每日”)组(n = 123)参与国家补铁计划,是从四个相邻村庄招募的。
两个每周补充组之间以及每周补铁组与“每日”组之间的新生儿体重和身长没有差异。孕期的铁和维生素A状况对新生儿体重和身长没有显著影响。男孩比女孩重100克,长0.53厘米(P < 0.05)。头胎新生儿比高胎次新生儿轻(P < 0.01),且往往更矮(P = 0.070)。母亲年龄、教育程度以及其他社会经济决定因素与新生儿体重和身长无关。新生儿体重的32%可由胎龄、母亲体重、产后测量、性别和产次解释,而新生儿身长的28%可由胎龄、母亲体重、产后测量、性别和母亲身高解释。
胎龄、孕中期母亲体重和婴儿性别是新生儿体重和身长的主要预测因素。
该研究得到了荷兰科学研究组织 - 荷兰热带研究促进基金会(NWO - WOTRO;WV 93 - 280)、荷兰内斯 - 范胡格施特拉滕基金会(IN 114)以及德国技术合作机构(GTZ)/印度尼西亚东南亚教育部长组织(SEAMEO)的支持。