Weiss D B, Levene C, Aboulafia Y, Isacsohn M
Fertil Steril. 1975 Sep;26(9):901-3. doi: 10.1016/s0015-0282(16)41355-5.
Blood group incompatibility as a cause of early or habitual abortion has been a matter of much debate. However, the abortion rate in such cases is much higher than that found in the general population. Two sisters having the rare genotype pp and anti-PP1Pk (anti-Tja) in their serum were reported as having habitual abortions; a third sister, with a normal P group, had a normal obstetric history. The relationship of anti-PP1Pk (anti-Tja) to the high rate of habitual abortion was discussed and added support was given to the existing evidence that certain maternal blood group antibodies can affect embryos early in uterine life.
血型不相容作为早期流产或习惯性流产的一个原因一直是一个备受争议的问题。然而,这类情况下的流产率远高于普通人群中的流产率。据报道,两姐妹血清中具有罕见的pp基因型和抗PP1Pk(抗Tja),她们有习惯性流产;第三个姐妹血型正常,产科病史正常。文中讨论了抗PP1Pk(抗Tja)与习惯性流产高发生率之间的关系,并进一步支持了现有证据,即某些母体血型抗体可在子宫内早期影响胚胎。