Wilkinson Michael H F
Institute for Mathematics and Computing Science, University of Groningen, The Netherlands.
IEEE Trans Biomed Eng. 2002 Oct;49(10):1077-85. doi: 10.1109/TBME.2002.803548.
The ecology of the human intestinal microflora and its interaction with the host are poorly understood. Though more and more data are being acquired, in part using modern molecular methods, development of a quantitative theory has not kept pace with this increase in observing power. This is in part due to the complexity of the system and to the lack of simulation environments in which to test what the ecological effect of a hypothetical mechanism of interaction would be, before resorting to laboratory experiments. The MIMICS project attempts to address this through the development of a cellular automaton for simulation of the intestinal microflora. In this paper, the design and evaluation of this simulator is discussed.
人类肠道微生物群的生态学及其与宿主的相互作用尚未得到充分了解。尽管越来越多的数据正在通过部分使用现代分子方法来获取，但定量理论的发展并未跟上这种观测能力的提升。这部分是由于该系统的复杂性以及缺乏模拟环境，在进行实验室实验之前，无法在其中测试假设的相互作用机制的生态效应。MIMICS项目试图通过开发一种用于模拟肠道微生物群的细胞自动机来解决这个问题。本文讨论了该模拟器的设计与评估。
