Germanakis John, Stiakaki Eftichia, Galanakis Emmanouil, Christidou Athanasia, Neonakis John, Dimitriou Helen, Tselentis Yiannis, Kalmanti Maria
Scand J Infect Dis. 2002;34(9):680-2. doi: 10.1080/00365540210147570.
Quantitative blood cultures have been used in order to define catheter-related bloodstream infection (CRBI) in pediatric patients with malignancy and central venous catheters (CVCs). We prospectively followed 32 patients with a total of 38 CVCs for a period of 4 y (14,068 catheter-days). Of a total of 35 cases of bacteremia, 9 were considered to be CRBI (25%). The incidence of bacteremia in our study was 2.48 episodes/1,000 catheter-days and 20/38 CVCs (52%) were affected by bacteremia. The incidence of CRBI was 0.63 episodes/1,000 catheter-days and it was detected in 9/38 CVCs (23%). The catheter salvage rate in cases of bacteremia, irrespective of etiology, was 30/35 (85%). The catheter salvage rate in cases of CRBI was only 4/9 (44%), whereas all the catheters (26/26) in non-catheter-related cases of bacteremia were salvaged. We suggest that the use of quantitative blood cultures is a useful tool for the evaluation of bacteremia in patients with CVCs and is of prognostic value.
为了确定患有恶性肿瘤且使用中心静脉导管（CVC）的儿科患者的导管相关血流感染（CRBI），已采用定量血培养。我们前瞻性地随访了32例患者，共38根CVC，为期4年（14,068导管日）。在总共35例菌血症病例中，9例被认为是CRBI（25%）。我们研究中的菌血症发生率为2.48例/1000导管日，38根CVC中有20根（52%）受到菌血症影响。CRBI的发生率为0.63例/1000导管日，在38根CVC中有9根（23%）检测到CRBI。无论病因如何，菌血症病例中的导管挽救率为30/35（85%）。CRBI病例中的导管挽救率仅为4/9（44%），而非导管相关菌血症病例中的所有导管（26/26）均被挽救。我们认为，定量血培养的应用是评估CVC患者菌血症的有用工具，具有预后价值。
