Maaser Kerstin, Grabowski Patricia, Sutter Andreas P, Höpfner Michael, Foss Hans-Dieter, Stein Harald, Berger Gerd, Gavish Moshe, Zeitz Martin, Scherübl Hans
Medical Clinic I and Department of Surgery, University Hospital Benjamin Franklin, Free University of Berlin, 12200 Berlin, Germany.
Clin Cancer Res. 2002 Oct;8(10):3205-9.
The peripheral benzodiazepine receptor (PBR) has been implicated in the growth control of colorectal cancer, where PBR-specific ligand-binding is increased 3-4-fold. However, the prognostic relevance of PBR (over) expression has not yet been evaluated in colorectal cancer.
A 5-year follow-up was performed in 116 consecutive patients undergoing surgery for colorectal cancer with regional or distant metastases [Union International Contre le Cancer (UICC) stage III, 59 patients; UICC stage IV, 57 patients]. The monoclonal anti-PBR antibody 8 D7 was used for immunohistochemical examination of paraffin-embedded sections. PBR-specific staining was compared in cancer tissues and normal mucosa. Kaplan-Meier survival curves were calculated.
Twenty-eight % of the colorectal cancers strongly overexpressed PBR. The mean survival of patients with stage III cancer was 56.2 +/- 9.2 months with and 86.8 +/- 6.6 months without high overexpression of PBR (P = 0.006). Univariate and multivariate analyses revealed that high PBR overexpression is an independent unfavorable prognostic factor in stage III colorectal cancer. In stage IV, however, the PBR status did not correlate with different survival times.
Strong PBR overexpression is a new independent prognostic marker in stage III colorectal cancer. Evaluating PBR overexpression may be useful for stratifying risk and developing risk-adapted strategies of adjuvant therapy.
外周苯二氮䓬受体（PBR）与结直肠癌的生长调控有关，在结直肠癌中PBR特异性配体结合增加3至4倍。然而，PBR（过）表达在结直肠癌中的预后相关性尚未得到评估。
对116例接受结直肠癌手术且伴有区域或远处转移的连续患者进行了5年随访[国际抗癌联盟（UICC）III期，59例患者；UICC IV期，57例患者]。使用单克隆抗PBR抗体8 D7对石蜡包埋切片进行免疫组化检查。比较癌组织和正常黏膜中PBR特异性染色情况。计算Kaplan-Meier生存曲线。
28%的结直肠癌强烈过表达PBR。III期癌症患者中，PBR高过表达组的平均生存期为56.2±9.2个月，无高过表达组为86.8±6.6个月（P = 0.006）。单因素和多因素分析显示，PBR高过表达是III期结直肠癌的一个独立不良预后因素。然而，在IV期，PBR状态与不同生存期无关。
PBR强烈过表达是III期结直肠癌一个新的独立预后标志物。评估PBR过表达可能有助于风险分层及制定风险适应性辅助治疗策略。
