Throndson Roger R, Sexton S Barrett
Department of Surgery, University of Texas Medical Branch Galveston, TX 77555-0531, USA.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002 Oct;94(4):413-9. doi: 10.1067/moe.2002.127582.
The purpose of this study was to evaluate the effectiveness of bioactive glass used as a graft material for regeneration of bone after the removal of impacted third molars. The healing distal to the second molars was followed, with documentation of the level of radiographic osseous fill and measurement of the changes in clinical attachment levels.
Fourteen (5 male and 9 female) patients completed the study at 1 year. After surgical removal of bilateral impacted third molars, one site was grafted with bioactive glass particles (BioGran, Orthovita, Malvern, Penn). The patients were followed up at 1 and 2 weeks after surgery for signs or symptoms of infection or any other complications that may have been related to the surgical procedures. At 3, 6, and 12 months, the clinical attachment levels distal to the second molars were assessed. At 6 and 12 months, radiographs were obtained to assess the amount of osseous fill distal to the second molars.
A split-mouth design was used to test the efficacy of the grafting materials. Clinical attachment levels in the grafted sites were significantly higher than in the nongrafted sites. There was not a significant increase in bone formation when comparing the 2 sides at 1 year.
This study suggests that treatment of third molar extraction sites with bioactive glass does significantly alter the clinical attachment level but not the level of osseous fill distal to the second molars after 1 year.
本研究旨在评估生物活性玻璃作为移植材料用于拔除阻生第三磨牙后骨再生的有效性。对第二磨牙远中侧的愈合情况进行跟踪，记录影像学骨填充水平并测量临床附着水平的变化。
14名患者（5名男性和9名女性）在1年后完成了该研究。在手术拔除双侧阻生第三磨牙后，一个部位植入生物活性玻璃颗粒（BioGran，Orthovita，马尔文，宾夕法尼亚州）。在术后1周和2周对患者进行随访，观察是否有感染迹象或症状或任何可能与手术操作相关的其他并发症。在3个月、6个月和12个月时，评估第二磨牙远中侧的临床附着水平。在6个月和12个月时，拍摄X线片以评估第二磨牙远中侧的骨填充量。
采用双侧对照设计来测试移植材料的疗效。植入部位的临床附着水平显著高于未植入部位。1年后比较两侧时，骨形成没有显著增加。
本研究表明用生物活性玻璃治疗第三磨牙拔除部位确实会显著改变临床附着水平，但1年后不会改变第二磨牙远中侧的骨填充水平。
