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功能化吡啶硼酸及其用于生成新型杂芳基吡啶的铃木交叉偶联反应。

Functionalized pyridylboronic acids and their Suzuki cross-coupling reactions to yield novel heteroarylpyridines.

作者信息

Parry Paul R, Wang Changsheng, Batsanov Andrei S, Bryce Martin R, Tarbit Brian

机构信息

Department of Chemistry, University of Durham, Durham, DH1 3LE England.

出版信息

J Org Chem. 2002 Oct 18;67(21):7541-3. doi: 10.1021/jo020388b.

DOI:10.1021/jo020388b
PMID:12375993
Abstract

2-Bromo-5-pyridylboronic acid 2a, 2-chloro-5-pyridylboronic acid 2b, 2-methoxy-5-pyridylboronic acid 2c, and 5-chloro-2-methoxy-4-pyridylboronic acid 4 have been synthesized and shown to undergo palladium-catalyzed cross-coupling reactions with heteroaryl bromides to yield novel heteroarylpyridine derivatives. The X-ray crystal structures of 2a and 2b have been obtained.

摘要

已合成出2-溴-5-吡啶硼酸2a、2-氯-5-吡啶硼酸2b、2-甲氧基-5-吡啶硼酸2c和5-氯-2-甲氧基-4-吡啶硼酸4，并表明它们能与杂芳基溴化物发生钯催化的交叉偶联反应，生成新型杂芳基吡啶衍生物。已获得2a和2b的X射线晶体结构。

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