二氯嘧啶的一锅法双铃木偶联反应
One-pot Double Suzuki Couplings of Dichloropyrimidines.
作者信息
Anderson Samantha C, Handy Scott T
出版信息
Synthesis (Stuttg). 2010 Aug 1;2010(16):2721-2724. doi: 10.1055/s-0030-1258150.
Abstract
An effective one-pot, regioselective double Suzuki coupling of 2,4-dichloropyrimidine has been developed, which enables the quick and efficient synthesis of diarylated pyrimidines. The choice of solvent proved critical to the success of this reaction sequence, with alcoholic solvent mixtures affording much greater reactivity and correspondingly lower temperatures than the use of polar aprotic solvents.
摘要
已开发出一种有效的一锅法、区域选择性的2,4-二氯嘧啶双铃木偶联反应，该反应能够快速有效地合成二芳基嘧啶。事实证明，溶剂的选择对该反应序列的成功至关重要，与使用极性非质子溶剂相比，醇类混合溶剂具有更高的反应活性，相应的反应温度也更低。
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