Sigurs Nele
Paediatric Department, Borås Central Hospital, Borås, Sweden.
Paediatr Respir Rev. 2002 Sep;3(3):177-83. doi: 10.1016/s1526-0542(02)00191-4.
This paper reviews the results from a cohort study in which 47 children hospitalised with respiratory syncytial virus (RSV) bronchiolitis and their 93 controls, matched for age, sex and place of living, were prospectively followed-up at the mean ages of 1, 3 and 7.5. Asthma was significantly more common in the RSV bronchiolitis group at all times. Asthma during the year prior to follow-up at age 7.5 was seen in 23% of the RSV children and in 2% of the controls (P < 0.001). Allergic sensitisation was found in 41% of the RSV children and in 22% of the controls (P = 0.039). When comparing these results with findings from other studies it is obvious that the rate of asthma and other bronchial obstructive symptoms are increased after RSV bronchiolitis but the various results concerning allergic sensitisation are not conclusive. Prospective studies are needed with some kind of randomised intervention against RSV before the mechanisms behind the post-bronchiolitic symptoms and the possibly increased risk for IgE mediated allergy can be settled.
本文回顾了一项队列研究的结果，该研究对47名因呼吸道合胞病毒（RSV）细支气管炎住院的儿童及其93名年龄、性别和居住地相匹配的对照儿童进行了前瞻性随访，随访的平均年龄分别为1岁、3岁和7.5岁。在各个时间点，RSV细支气管炎组中哮喘的发生率显著更高。在7.5岁随访前一年，23%的RSV感染儿童出现哮喘，而对照组中这一比例为2%（P<0.001）。41%的RSV感染儿童存在过敏致敏，而对照组中这一比例为22%（P = 0.039）。将这些结果与其他研究的发现进行比较时，很明显RSV细支气管炎后哮喘和其他支气管阻塞症状的发生率会增加，但关于过敏致敏的各种结果尚无定论。在解决细支气管炎后症状背后的机制以及IgE介导的过敏可能增加的风险之前，需要进行一些针对RSV的随机干预的前瞻性研究。
