Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada.
Division of Biotechnology, Department of Pathobiology, School of Veterinary Medicine, Shiraz University, Shiraz 71557-13876, Iran.
Cells. 2022 Apr 13;11(8):1322. doi: 10.3390/cells11081322.
Evidence suggests that neutrophils exert specialized effector functions during infection and inflammation, and that these cells can affect the duration, severity, and outcome of the infection. These functions are related to variations in phenotypes that have implications in immunoregulation during viral infections. Although the complexity of the heterogeneity of neutrophils is still in the process of being uncovered, evidence indicates that they display phenotypes and functions that can assist in viral clearance or augment and amplify the immunopathology of viruses. Therefore, deciphering and understanding neutrophil subsets and their polarization in viral infections is of importance. In this review, the different phenotypes of neutrophils and the roles they play in viral infections are discussed. We also examine the possible ways to target neutrophil subsets during viral infections as potential anti-viral treatments.
有证据表明，中性粒细胞在感染和炎症期间发挥专门的效应功能，并且这些细胞可以影响感染的持续时间、严重程度和结果。这些功能与表型的变化有关，这些变化对病毒感染期间的免疫调节有影响。尽管中性粒细胞异质性的复杂性仍在研究中，但有证据表明，它们表现出的表型和功能可以帮助清除病毒，或增强和放大病毒的免疫病理。因此，解析和理解病毒感染中的中性粒细胞亚群及其极化状态非常重要。在这篇综述中，我们讨论了中性粒细胞的不同表型及其在病毒感染中的作用。我们还研究了在病毒感染期间靶向中性粒细胞亚群的可能方法，作为潜在的抗病毒治疗方法。
