Ramasubbu R
Department of Psychiatry, University of Calgary, Foothills Hospital, Canada.
Med Hypotheses. 2002 Nov;59(5):537-51. doi: 10.1016/s0306-9877(02)00244-x.
The association of depression with insulin resistance (IR) and athersclerotic vascular diseases has been well documented. This review examines the relevance of IR as a link between depressive disorder and atherosclerotic vascular diseases. Relevant articles collected from Medline database over the period of 1966-2001 were reviewed. Studies have shown that IR is a state-dependent abnormality in depression and depression increases the risk of vascular morbidity and mortality. Given that IR is a central component of cardiovascular risk factors, depression-related IR might play a role in the development and progression of coronary and cerebral atherosclerosis in chronic-resistant depression. Further, IR may contribute to the pathophysiology of depressive disorder. In conclusion IR could account for the linkage between depression and atherosclerotic vascular diseases. More studies are needed to examine the importance of improving insulin sensitivity in the treatment of chronic-resistant depression and prevention of depression-related vascular morbidity and mortality.
抑郁症与胰岛素抵抗（IR）及动脉粥样硬化性血管疾病之间的关联已有充分记录。本综述探讨了IR作为抑郁症与动脉粥样硬化性血管疾病之间联系的相关性。对1966年至2001年期间从Medline数据库收集的相关文章进行了综述。研究表明，IR是抑郁症中一种状态依赖性异常，抑郁症会增加血管发病和死亡风险。鉴于IR是心血管危险因素的核心组成部分，与抑郁症相关的IR可能在慢性难治性抑郁症患者的冠状动脉和脑动脉粥样硬化的发生和发展中起作用。此外，IR可能促成抑郁症的病理生理学过程。总之，IR可以解释抑郁症与动脉粥样硬化性血管疾病之间的联系。需要更多研究来检验改善胰岛素敏感性在治疗慢性难治性抑郁症以及预防与抑郁症相关的血管发病和死亡方面的重要性。
