Liaw Fang-Yih, Kao Tung-Wei, Hsueh Ju-Ting, Chan Yi-Hsin, Chang Yaw-Wen, Chen Wei-Liang
Division of Family Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan; Division of Geriatric Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Division of Family Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan; Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan.
Biomed Res Int. 2015;2015:586251. doi: 10.1155/2015/586251. Epub 2015 Dec 7.
Metabolic syndrome (MetS) has been reported with an increased risk of depression. MetS was also associated with insulin resistance. This study aimed to evaluate whether MetS components might contribute to depression in participants with insulin resistance (IR) or not.
This study included 3,331 participants ≥18 years in the NHANES 2009-2010. Depressive symptoms were assessed using the Patient Health Questionnaire-9 (PHQ-9). MetS components were measured using blood chemistry and body measurements. IR was identified using the homeostasis model assessment method.
Predicted PHQ-9 scores significantly increased as the number of MetS components increased in patients with IR. The adjusted β coefficients of the predicted PHQ-9 score with 2, 4, and 5 MetS components were 1.803, 2.081, and 3.048, respectively (P for trend < 0.05). Low HDL-C levels were significantly associated with higher predicted total PHQ-9 scores in fully adjusted models in the IR group (P < 0.05).
The results indicated that the presence of a greater number of components of MetS was significantly associated with higher predicted total PHQ-9 scores in participants with IR. Among the components of MetS, the most apparent association was observed between low HDL and higher predicted total PHQ-9 scores.
已有报道称代谢综合征（MetS）会增加患抑郁症的风险。MetS还与胰岛素抵抗有关。本研究旨在评估MetS的各个组成部分是否会对胰岛素抵抗（IR）参与者的抑郁症产生影响。
本研究纳入了2009 - 2010年美国国家健康与营养检查调查（NHANES）中3331名年龄≥18岁的参与者。使用患者健康问卷-9（PHQ-9）评估抑郁症状。通过血液化学检测和身体测量来测定MetS的各个组成部分。采用稳态模型评估方法来识别胰岛素抵抗。
在患有胰岛素抵抗的患者中，随着MetS组成部分数量的增加，预测的PHQ-9得分显著升高。具有2个、4个和5个MetS组成部分的预测PHQ-9得分的调整β系数分别为1.803、2.081和3.048（趋势P<0.05）。在胰岛素抵抗组的完全调整模型中，低高密度脂蛋白胆固醇（HDL-C）水平与较高的预测总PHQ-9得分显著相关（P<0.05）。
结果表明，在胰岛素抵抗的参与者中，更多数量的MetS组成部分与较高的预测总PHQ-9得分显著相关。在MetS的各个组成部分中，观察到低HDL与较高的预测总PHQ-9得分之间存在最明显的关联。
