Limburg Paul J, Stolzenberg-Solomon Rachael Z, Colbert Lisa H, Perez-Perez Guillermo I, Blaser Martin J, Taylor Philip R, Virtamo Jarmo, Albanes Demetrius
Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota 55905, USA.
Cancer Epidemiol Biomarkers Prev. 2002 Oct;11(10 Pt 1):1095-9.
Because Helicobacter pylori colonization can produce systemic as well as local effects, it may be associated with carcinogenesis in extra gastric target organs. The currently available data regarding a possible link between H. pylori seropositivity and colorectal cancer risk are limited and inconclusive. In this prospective case-control study nested within the Alpha-Tocopherol, Beta-Carotene Study cohort of Finnish male smokers aged 50-69 years, we examined the association between H. pylori seropositivity and incident colorectal adenocarcinoma. Separate risk estimates were derived by colorectal cancer anatomical subsite and by H. pylori CagA seropositivity status. Demographic, dietary, and lifestyle variables were accounted for in the data analyses using information obtained from a prerandomization questionnaire and physical examination. Baseline serum samples from 118 cases and 236 matched controls were assayed for both H. pylori whole cell and H. pylori CagA antibodies. In total, 258 (73%) and 212 (60%) subjects expressed whole cell and CagA antibodies, respectively. H. pylori seropositivity, defined as one or both antibody assays positive, was present in 273 (77%) subjects. None of the seropositivity results were statistically different between cases and controls. Multivariate odds ratio (95% confidence interval) estimates for whole cell, cagA, and H. pylori seropositivity were 1.05 (0.63-1.74), 1.17 (0.74-1.84), and 0.91 (0.53-1.55), respectively. Stratification by colorectal cancer subsite yielded similarly unremarkable results. On the basis of these data, H. pylori carriage does not appear to be an important risk factor for colorectal adenocarcinoma.
由于幽门螺杆菌定植可产生全身及局部影响，它可能与胃外靶器官的致癌作用有关。目前关于幽门螺杆菌血清阳性与结直肠癌风险之间可能联系的数据有限且尚无定论。在这项嵌套于芬兰50 - 69岁男性吸烟者的α - 生育酚、β - 胡萝卜素研究队列中的前瞻性病例对照研究中，我们研究了幽门螺杆菌血清阳性与结直肠癌发病之间的关联。通过结直肠癌解剖亚部位以及幽门螺杆菌CagA血清阳性状态得出单独的风险估计值。在数据分析中，使用从随机分组前问卷和体格检查获得的信息对人口统计学、饮食和生活方式变量进行了考量。对118例病例和236例匹配对照的基线血清样本检测了幽门螺杆菌全细胞抗体和幽门螺杆菌CagA抗体。总共有258名（73%）和212名（60%）受试者分别表达了全细胞抗体和CagA抗体。幽门螺杆菌血清阳性定义为一项或两项抗体检测呈阳性，273名（77%）受试者存在该情况。病例组和对照组之间的血清阳性结果在统计学上均无差异。全细胞、CagA和幽门螺杆菌血清阳性的多因素比值比（95%置信区间）估计值分别为1.05（0.63 - 1.74）、1.17（0.74 - 1.84）和0.91（0.53 - 1.55）。按结直肠癌亚部位分层得出的结果同样不显著。基于这些数据，幽门螺杆菌携带似乎不是结直肠癌的重要危险因素。
