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本文引用的文献

1
Gammadelta T cells: functional plasticity and heterogeneity.γδ T细胞：功能可塑性与异质性
Nat Rev Immunol. 2002 May;2(5):336-45. doi: 10.1038/nri797.
2
A role for skin gammadelta T cells in wound repair.皮肤γδ T细胞在伤口修复中的作用。
Science. 2002 Apr 26;296(5568):747-9. doi: 10.1126/science.1069639.
3
rHuKGF ameliorates symptoms in DSS and CD4(+)CD45RB(Hi) T cell transfer mouse models of inflammatory bowel disease.重组人角质形成细胞生长因子可改善炎症性肠病的葡聚糖硫酸钠和CD4(+)CD45RB(Hi) T细胞转移小鼠模型中的症状。
Am J Physiol Gastrointest Liver Physiol. 2002 Apr;282(4):G690-701. doi: 10.1152/ajpgi.00314.2001.
4
Intraepithelial lymphocytes: exploring the Third Way in immunology.上皮内淋巴细胞：探索免疫学的第三条道路。
Nat Immunol. 2001 Nov;2(11):997-1003. doi: 10.1038/ni1101-997.
5
Biological insights into TCRgammadelta+ and TCRalphabeta+ intraepithelial lymphocytes provided by serial analysis of gene expression (SAGE).通过基因表达系列分析（SAGE）对TCRγδ⁺和TCRαβ⁺上皮内淋巴细胞的生物学见解。
Immunity. 2001 Sep;15(3):419-34. doi: 10.1016/s1074-7613(01)00192-3.
6
Attributes of gammadelta intraepithelial lymphocytes as suggested by their transcriptional profile.γδ上皮内淋巴细胞的转录谱所提示的特征
Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10261-6. doi: 10.1073/pnas.171320798.
7
Clonal expansion of CD4+ TCRbetabeta+ T cells in TCR alpha-chain- deficient mice by gut-derived antigens.肠道来源抗原导致TCRα链缺陷小鼠中CD4⁺ TCRββ⁺ T细胞的克隆性扩增。
J Immunol. 1999 Feb 1;162(3):1843-50.
8
The critical role of interleukin 4 but not interferon gamma in the pathogenesis of colitis in T-cell receptor alpha mutant mice.白细胞介素4而非干扰素γ在T细胞受体α突变小鼠结肠炎发病机制中的关键作用。
Gastroenterology. 1999 Feb;116(2):320-6. doi: 10.1016/s0016-5085(99)70128-9.
9
Characterization of recombinant human fibroblast growth factor (FGF)-10 reveals functional similarities with keratinocyte growth factor (FGF-7).重组人成纤维细胞生长因子（FGF）-10的特性揭示了其与角质形成细胞生长因子（FGF-7）的功能相似性。
J Biol Chem. 1998 May 22;273(21):13230-5. doi: 10.1074/jbc.273.21.13230.
10
Current concepts in mucosal immunity. III. Ontogeny and function of gamma delta T cells in the intestine.黏膜免疫的当前概念。III. 肠道中γδ T细胞的个体发生与功能
Am J Physiol. 1998 Mar;274(3):G455-8. doi: 10.1152/ajpgi.1998.274.3.G455.

上皮内γδ T细胞对肠黏膜的保护作用。

Protection of the intestinal mucosa by intraepithelial gamma delta T cells.

作者信息

Chen Yaping, Chou Kevin, Fuchs Elaine, Havran Wendy L, Boismenu Richard

机构信息

Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

出版信息

Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14338-43. doi: 10.1073/pnas.212290499. Epub 2002 Oct 10.

DOI:10.1073/pnas.212290499
PMID:12376619
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC137885/
Abstract

gammadelta intraepithelial T lymphocytes (IEL) represent a major T cell population within the intestine of unclear functional relevance. The role of intestinal gammadelta IEL was evaluated in the dextran sodium sulfate (DSS) induced mouse colitis model system. Large numbers of gammadelta T cells, but not alphabeta T cells, were localized at sites of DSS-induced epithelial cell damage. gammadelta IEL in DSS treated mice expressed keratinocyte growth factor (KGF), a potent intestinal epithelial cell mitogen. gammadelta cell-deficient mice (TCRdelta(-/-)) and KGF-deficient mice (KGF(-/-)), but not alphabeta cell-deficient mice (TCRalpha(-/-)), were more prone than wild-type mice to DSS-induced mucosal injury and demonstrated delayed tissue repair after termination of DSS treatment. Termination of DSS treatment resulted in vigorous epithelial cell proliferation in wild-type mice but not in TCRdelta(-/-) mice or KGF(-/-) mice. These results suggest that gammadelta IEL help preserve the integrity of damaged epithelial surfaces by providing the localized delivery of an epithelial cell growth factor.

摘要

γδ上皮内T淋巴细胞（IEL）是肠道内主要的T细胞群体，其功能相关性尚不清楚。在葡聚糖硫酸钠（DSS）诱导的小鼠结肠炎模型系统中评估了肠道γδ IEL的作用。大量的γδ T细胞而非αβ T细胞定位于DSS诱导的上皮细胞损伤部位。DSS处理小鼠中的γδ IEL表达角质形成细胞生长因子（KGF），这是一种有效的肠上皮细胞促有丝分裂原。γδ细胞缺陷小鼠（TCRδ（-/-））和KGF缺陷小鼠（KGF（-/-）），而非αβ细胞缺陷小鼠（TCRα（-/-）），比野生型小鼠更易发生DSS诱导的黏膜损伤，并且在DSS处理终止后显示出组织修复延迟。DSS处理的终止导致野生型小鼠中上皮细胞剧烈增殖，但在TCRδ（-/-）小鼠或KGF（-/-）小鼠中则不然。这些结果表明，γδ IEL通过提供上皮细胞生长因子的局部递送，有助于维持受损上皮表面的完整性。