Sancak T, Silav G, Egemen N, Aldur M
Department of Radiology, Faculty of Medicine, Ankara University, Ibn-Sina Hospital, Sihhiye, Ankara, Turkey.
Acta Neurochir (Wien). 2002 Sep;144(9):929-31. doi: 10.1007/s00701-002-0989-3.
Chronic cerebral vasospasm is delayed-onset cerebral arterial narrowing in response to blood clots left in the subarachnoid space after aneurysmal subarachnoid haemorrhage (SAH). Rabbit models of vasospasm have been developed as in vivo experimental pathogenesis and the treatments of cerebral vasospasm using human vessels are not possible. The present study assessed the diagnostic accuracy of the intravenous digital subtraction angiography (IV-DSA) in chronic cerebral arterial spasm following induced SAH in the rabbit.
Ten rabbits' left leg veins catheterised by intravascular access needle and 3F catheters introduced to the right leg arteries probing the proximal of the vertebral arteries. Initially IV-DSA and intra-arterial digital subtraction angiography (IA-DSA) was performed. Three millilitres of fresh autologous arterial blood was injected into the cisterna magna of the ten rabbits' in order to produce in vivo model of chronic SAH. Angiograms were obtained 15 minutes and 72 hours after the SAH.
Diameters of the basilar arteries were similar to each other in both methods and reduced after the SAH.
The present study shows that IV-DSA is a relatively simple and effective method for demonstrating cerebral vessels, especially the basilar artery.
慢性脑血管痉挛是动脉瘤性蛛网膜下腔出血（SAH）后，蛛网膜下腔残留血凝块所引发的迟发性脑动脉狭窄。由于无法使用人体血管进行脑血管痉挛的体内实验发病机制及治疗研究，因此已建立了兔脑血管痉挛模型。本研究评估了静脉数字减影血管造影（IV-DSA）对兔诱导性SAH后慢性脑动脉痉挛的诊断准确性。
通过血管穿刺针将10只兔子的左腿静脉插管，并将3F导管插入右腿动脉，探测椎动脉近端。首先进行IV-DSA和动脉数字减影血管造影（IA-DSA）。向10只兔子的枕大池注入3毫升新鲜自体动脉血，以建立慢性SAH的体内模型。SAH后15分钟和72小时获取血管造影图像。
两种方法测得的基底动脉直径相似，SAH后基底动脉直径减小。
本研究表明，IV-DSA是一种相对简单有效的显示脑血管，尤其是基底动脉的方法。
