Vieregge P
Klinik für Neurologie mit klinischer Neurophysiologie, Klinikum Lippe-Lemgo, Germany.
Nervenarzt. 2002 Oct;73(10):982-9. doi: 10.1007/s00115-002-1394-0.
Retrospective case-control studies among patients with idiopathic Parkinson's syndrome (IPS) show a positive association to the existence of a - mostly premorbid - exposure to pesticides. In acute pesticide intoxications, usually symptoms other than parkinsonism are found. Therefore, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) continues to be the agent best documented both experimentally and clinically to cause a clinical syndrome comparable to IPS. It is debated whether still unknown effects between exogenous pesticide exposure and the xenobiotic enzyme system may lead to IPS in single genetically susceptible individuals. In practice, the present data on the problem of pesticide exposure in IPS are irrelevant for medicolegal considerations.
对特发性帕金森综合征（IPS）患者进行的回顾性病例对照研究表明，其与（大多在病前）接触杀虫剂之间存在正相关。在急性杀虫剂中毒中，通常会出现帕金森综合征以外的症状。因此，1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）仍然是在实验和临床方面都有充分记录的、能导致与IPS相似临床综合征的药物。外源杀虫剂暴露与异生物质酶系统之间仍未知的效应是否会在单一基因易感个体中导致IPS，这一点存在争议。实际上，目前关于IPS中杀虫剂暴露问题的数据与法医学考量无关。
